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Literature summary extracted from

  • Wiedmann, S.; Eudy, J.D.; Zempleni, J.
    Biotin supplementation increases expression of genes encoding interferon-gamma, interleukin-1beta, and 3-methylcrotonyl-CoA carboxylase, and decreases expression of the gene encoding interleukin-4 in human peripheral blood mononuclear cells (2003), J. Nutr., 133, 716-719.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.4.1.4 reverse transcriptase PCR Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.4.1.4 ATP + 3-methylcrotonyl-CoA + HCO3- Homo sapiens catalyzes essential steps in the metabolism of amino acids ADP + phosphate + 3-methylglutaconyl-CoA
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 ir

Organism

EC Number Organism UniProt Comment Textmining
6.4.1.4 Homo sapiens
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 human, healthy caucasian adults
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Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.4.1.4 ATP + 3-methylcrotonyl-CoA + HCO3-
-
 Homo sapiens ADP + phosphate + 3-methylglutaconyl-CoA
-
 ir
6.4.1.4 ATP + 3-methylcrotonyl-CoA + HCO3- catalyzes essential steps in the metabolism of amino acids Homo sapiens ADP + phosphate + 3-methylglutaconyl-CoA
-
 ir

Cofactor

EC Number Cofactor Comment Organism Structure
6.4.1.4 biotin plays a role in regualtion of gene expression in addition to its role as a covalently bound group, biotin supplementation causes increase expression of the gene encoding 3-methylcrotonyl-CoA carboxylase alpha chain Homo sapiens