Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Tchantchou, F.; Graves, M.; Ashline, D.; Morin, A.; Pimenta, A.; Ortiz, D.; Rogers, E.; Shea, T.B.
    Increased transcription and activity of glutathione synthase in response to deficiencies in folate, vitamin E, and apolipoprotein E (2004), J. Neurosci. Res., 75, 508-515.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.3.2.3 additional information folate and vitamin E depletion leads to 18% increased enzyme expression and activity, mice mutants lacking apolipoprotein E show even higher activation rates of 31% on minimal diet compared to the wild-type on normal diet Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
6.3.2.3 additional information ApoE-deficient mice show reduced enzyme expression and activity Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.3 ATP + gamma-L-Glu-L-Cys + Gly Mus musculus ApoE-deficient mice show reduced enzyme expression and activity, genetic regulation mechanism, overview ADP + phosphate + glutathione
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.3 Mus musculus
-
 normal and ApoE-/- mice
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.2.3 partial from brain Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.2.3 brain
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.3.2.3 3 8 about, wild-type mice on minimal diet Mus musculus
6.3.2.3 32
-
 about, ApoE-deficient mice on normal diet Mus musculus
6.3.2.3 33.5
-
 about, wild-type mice on normal diet Mus musculus
6.3.2.3 43
-
 about, ApoE-deficient mice on minimal diet Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.3 ATP + gamma-L-Glu-L-Cys + Gly
-
 Mus musculus ADP + phosphate + glutathione
-
 ?
6.3.2.3 ATP + gamma-L-Glu-L-Cys + Gly ApoE-deficient mice show reduced enzyme expression and activity, genetic regulation mechanism, overview Mus musculus ADP + phosphate + glutathione
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.2.3 GS
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
6.3.2.3 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3.2.3 8
-
 assay at Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.2.3 ATP
-
 Mus musculus