Literature summary extracted from

Prevost, M.; Van Belle, D.; Tulkens, P.M.; Courvalin, P.; Van Bambeke, F.
Modeling of Enterococcus faecalis D-alanine:D-alanine ligase: structure-based study of the active site in the wild-type enzyme and in glycopeptide-dependent mutants (2000), J. Mol. Microbiol. Biotechnol., 2, 321-330.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
6.3.2.4	D-cycloserine	weak inhibition	Enterococcus faecalis
6.3.2.4	methylphosphinophosphate	strong inhibition	Enterococcus faecalis

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
6.3.2.4	ATP + D-alanine	Enterococcus faecalis	essential enzyme	ADP + phosphate + D-alanyl-D-alanine	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
6.3.2.4	Enterococcus faecalis	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6.3.2.4	ATP + D-alanine	-	Enterococcus faecalis	ADP + phosphate + D-alanyl-D-alanine	-	?
6.3.2.4	ATP + D-alanine	essential enzyme	Enterococcus faecalis	ADP + phosphate + D-alanyl-D-alanine	-	?

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Release 2023.1 (January 2023)