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Literature summary extracted from

  • Eaazhisai, K.; Jayalakshmi, R.; Gayathri, P.; Anand, R.P.; Sumathy, K.; Balaram, H.; Murthy, M.R.
    Crystal structure of fully ligated adenylosuccinate synthetase from Plasmodium falciparum (2004), J. Mol. Biol., 335, 1251-1264.
    View publication on PubMed

Application

EC Number Application Comment Organism
6.3.4.4 medicine enzymes of the salvage pathway are good targets for anti-parasitic drugs Plasmodium falciparum

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.4.4 expressed in Escherichia coli BL21 (DE3) Plasmodium falciparum

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
6.3.4.4 space group C222(1), cell parameters a = 91.58 A, b = 117.12 A, c = 80.42A Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.4.4 Hadacidin
-
 Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.4.4 GTP + IMP + L-aspartate Plasmodium falciparum salvage pathway, catalyzing the first committed step in the synthesis of AMP from IMP GDP + phosphate + adenylosuccinate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.4 Plasmodium falciparum Q9U8D3
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.4.4
-
 Plasmodium falciparum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.4 GTP + IMP + L-aspartate
-
 Plasmodium falciparum GDP + phosphate + adenylosuccinate
-
 ?
6.3.4.4 GTP + IMP + L-aspartate salvage pathway, catalyzing the first committed step in the synthesis of AMP from IMP Plasmodium falciparum GDP + phosphate + adenylosuccinate
-
 ?

Subunits

EC Number Subunits Comment Organism
6.3.4.4 dimer
-
 Plasmodium falciparum

Synonyms

EC Number Synonyms Comment Organism
6.3.4.4 Adenylosuccinate synthetase
-
 Plasmodium falciparum
6.3.4.4 AdSS
-
 Plasmodium falciparum
6.3.4.4 PfAdSS
-
 Plasmodium falciparum