EC Number | Crystallization (Comment) | Organism |
---|---|---|
6.1.1.15 | native enzyme or enzyme complexed with L-proline, tRNAPro isoacceptors, ATP-Mn2+, prolyl-adenylate intermediate, or prolyl-adenylate analogue Pro-AMS, preparation by soaking of native enzyme crystals in ligand solutions, X-ray diffraction structure determination at 2.85-3.0 A resolution | Thermus thermophilus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
6.1.1.15 | Zn2+ | - |
Thermus thermophilus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.1.1.15 | ATP + L-proline + tRNAPro | Thermus thermophilus | - |
AMP + diphosphate + L-prolyl-tRNAPro | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
6.1.1.15 | Thermus thermophilus | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
6.1.1.15 | ATP + L-proline + tRNAPro = AMP + diphosphate + L-prolyl-tRNAPro | induced fit substrate recognition, reaction mechanism, proline binding site structure | Thermus thermophilus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.1.1.15 | ATP + L-proline + tRNAPro | - |
Thermus thermophilus | AMP + diphosphate + L-prolyl-tRNAPro | - |
? | |
6.1.1.15 | ATP + L-proline + tRNAPro | binding of L-proline and ATP causes conformational changes in the proline binding loop and motif 2 loop, formation of an activated prolyl-adenylate reaction intermediate, required for the final conformational ordering of a ten residue peptide, the ordered loop, close to the active site | Thermus thermophilus | AMP + diphosphate + L-prolyl-tRNAPro | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
6.1.1.15 | Global RNA synthesis factor | - |
Thermus thermophilus |
6.1.1.15 | Pro-tRNA synthetase | - |
Thermus thermophilus |
6.1.1.15 | Proline translase | - |
Thermus thermophilus |
6.1.1.15 | Proline--tRNA ligase | - |
Thermus thermophilus |
6.1.1.15 | Prolyl RNA synthetase | - |
Thermus thermophilus |
6.1.1.15 | Prolyl-transfer ribonucleate synthetase | - |
Thermus thermophilus |
6.1.1.15 | Prolyl-transfer ribonucleic acid synthetase | - |
Thermus thermophilus |
6.1.1.15 | Prolyl-transfer RNA synthetase | - |
Thermus thermophilus |
6.1.1.15 | Prolyl-tRNA synthetase | - |
Thermus thermophilus |
6.1.1.15 | ProRS | - |
Thermus thermophilus |
6.1.1.15 | ProRSTT | - |
Thermus thermophilus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
6.1.1.15 | ATP | - |
Thermus thermophilus |