Literature summary extracted from

Gall, A.L.; Ruff, M.; Kannan, R.; Cuniasse, P.; Yiotakis, A.; Dive, V.; Rio, M.C.; Basset, P.; Moras, D.
Crystal structure of the stromelysin-3 (MMP-11) catalytic domain complexed with a phosphinic inhibitor mimicking the transition-state (2001), J. Mol. Biol., 307, 577-586.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.4.24.B3	expression of catalytic domain connected to the hemopexin-like domain in Escherichia coli BL21(DE3)	Mus musculus

Crystallization (Commentary)

EC Number	Crystallization (Comment)	Organism
3.4.24.B3	catalytic domain complexed with a phosphinic inhibitor mimicking the transition state, hanging drop method, 5 mg/ml protein in 0.05 M MES, pH 5.5, 0.5 M ammonium sulfate, 1% v/v trifluoroethanol, 4°C, a few months, X-ray diffraction structure determination at 2.6 A resolution and analysis	Mus musculus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.24.B3	phosphinic inhibitor	inhibitor binding mechanism	Mus musculus

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
3.4.24.B3	Zinc	3 zinc atoms per enzyme molecule, metalloproteinase, the zinc binding site is catalytically active	Mus musculus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.4.24.B3	protein + H2O	Mus musculus	-	peptides	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.24.B3	Mus musculus	Q02853	precursor	-

Reaction

EC Number	Reaction	Comment	Organism	Reaction ID
3.4.24.B3	proteolytic degradation of proteins	mechanism	Mus musculus	a

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.24.B3	protein + H2O	-	Mus musculus	peptides	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.24.B3	M10.007	Merops-ID	Mus musculus
3.4.24.B3	matrix metalloproteinase-11	-	Mus musculus
3.4.24.B3	MMP-11	-	Mus musculus
3.4.24.B3	SL-3	-	Mus musculus
3.4.24.B3	ST3	-	Mus musculus

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Release 2023.1 (January 2023)