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Literature summary extracted from

  • Archontis, G.; Simonson, T.; Karplus, M.
    Binding free energies and free energy components from molecular dynamics and Poisson-Boltzmann calculations. Application to amino acid recognition by aspartyl-tRNA synthetase (2001), J. Mol. Biol., 306, 307-327.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
6.1.1.12 K198L exchange of the conserved residue leads to a slightly increased binding of Asp, binding of Asn is strongly increased to the level of Asp, no ability to adenylate Asn, molecular dynamic simulation, binding mechansim and free energy Escherichia coli
6.1.1.12 K198L/D233E slightly increased binding of Asp, binding of ASn is strongly increased to the level of Asp, no ability to adenylate Asn, molecular dynamic simulation, binding mechansim and free energy Escherichia coli
6.1.1.12 K198L/Q199E/D233E binding of Asp is strongly reduced, no ability to adenylate Asn, molecular dynamic simulation, binding mechansim and free energy Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.12 ATP + L-aspartate + tRNAAsp Escherichia coli
-
AMP + diphosphate + L-aspartyl-tRNAAsp
-
?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.12 Escherichia coli
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
6.1.1.12 ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp Asn binding sites K198 and H449, binding mechanism and free energies Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.12 ATP + L-asparagine + tRNAAsp
-
Escherichia coli AMP + diphosphate + L-asparaginyl-tRNAAsp
-
?
6.1.1.12 ATP + L-aspartate + tRNAAsp
-
Escherichia coli AMP + diphosphate + L-aspartyl-tRNAAsp
-
?
6.1.1.12 additional information determination of binding free energies Escherichia coli ?
-
?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.12 Aspartic acid translase
-
Escherichia coli
6.1.1.12 Aspartyl ribonucleate synthetase
-
Escherichia coli
6.1.1.12 aspartyl ribonuleic synthetase
-
Escherichia coli
6.1.1.12 Aspartyl-transfer ribonucleic acid synthetase
-
Escherichia coli
6.1.1.12 Aspartyl-transfer RNA synthetase
-
Escherichia coli
6.1.1.12 Aspartyl-tRNA synthetase
-
Escherichia coli