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Literature summary extracted from
- Selective degradation of unfolded proteins by the self-compartmentalizing HtrA protease, a periplasmic heat shock protein in Escherichia coli (1999), J. Mol. Biol., 294, 1363-1374.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.21.107 | periplasm | - |
Escherichia coli | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.107 | additional information | Escherichia coli | involved in the degradation of unfolded proteins | ? | - |
? |  |
| 3.4.21.107 | Protein + H2O | Escherichia coli | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.107 | Escherichia coli | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.21.107 | - |
Escherichia coli |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.107 | alpha-lactalbumin + H2O | acts on the fully unfolded protein but not on the native form | Escherichia coli | ? | - |
? | |
| 3.4.21.107 | casein + H2O | partially unfolded casein | Escherichia coli | ? | - |
? | |
| 3.4.21.107 | citrate synthase + H2O | acts on the thermally unfolded synthase but not on the native form | Escherichia coli | ? | - |
? | |
| 3.4.21.107 | insulin beta-chain + H2O | oxidized beta-chain which is fully unfolded | Escherichia coli | ? | - |
? | |
| 3.4.21.107 | malate dehydrogenase + H2O | acts on the thermally unfolded protein but not on the native form | Escherichia coli | ? | - |
? | |
| 3.4.21.107 | additional information | involved in the degradation of unfolded proteins | Escherichia coli | ? | - |
? | |
| 3.4.21.107 | Protein + H2O | - |
Escherichia coli | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.21.107 | dodecamer | consists of two stacks of hexameric rings, SDS-PAGE, cross-linking experiments | Escherichia coli |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.107 | HtrA | - |
Escherichia coli |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.107 | 55 | - |
- |
Escherichia coli |
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Release 2023.1 (January 2023)
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