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Literature summary extracted from

  • McDonald, J.P.; Maury, E.E.; Levine, A.S.; Woodgate, R.
    Regulation of UmuD cleavage: role of the amino-terminal tail (1998), J. Mol. Biol., 282, 721-730.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.B30
-
 Escherichia coli

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.B30 D20Y slight increase in activation rate by cleavage Escherichia coli
3.4.21.B30 F15L no change in activation rate by cleavage Escherichia coli
3.4.21.B30 I4F slight increase in activation rate by cleavage Escherichia coli
3.4.21.B30 L17F no change in activation rate by cleavage Escherichia coli
3.4.21.B30 Q23P mutant phenotype is reminiscent of the wild-type Escherichia coli
3.4.21.B30 Q23P/S60A UmuD is non-cleavable via an intramolecular cleavage pathway, but it remains cleavable via the intermolecular pathway Escherichia coli
3.4.21.B30 T14P no change in activation rate by cleavage Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B30 Escherichia coli
-
-
-
3.4.21.B30 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.B30 proteolytic modification RecA-mediated posttranslational processing of UmuD to the shorter, but mutagenically active UmuD' Escherichia coli
3.4.21.B30 proteolytic modification RecA-mediated posttranslational processing of UmuD to the shorter, but mutagenically active UmuD', Salmonella typhimurium UmuD is processed at a significantly faster rate than the Escherichia coli protein, enhanced cleavage can be attributed to the presence of a Pro23 residue Salmonella enterica subsp. enterica serovar Typhimurium

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.B30
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B30 S24.003 Merops ID Salmonella enterica subsp. enterica serovar Typhimurium