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Literature summary extracted from
- Biosynthesis of chondroitinase and hyaluronidase by different strains of Paracoccidioides brasiliensis (2003), J. Med. Microbiol., 52, 479-481.
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.2.1 | hyaluronan | Paracoccidioides brasiliensis | enzyme might be involved in the pathogenicity of the bacterium causing paracocidiodomycosis | 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.6.4 | Paracoccidioides brasiliensis | - |
isolated from humans, a penguin, an armadillo and dog food | - |
| 4.2.2.1 | Paracoccidioides brasiliensis | - |
different strains isolated from different host organisms, e.g. human, penguin, armadillo, and from dog food | - |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 4.2.2.1 | [hyaluronate]n = (4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine-[hyaluronate]n-m-1 + 2 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + hyaluronate | also acts on chondroitin, the product is more systematically known as 3-(4-deoxy-alpha-L-threo-hex-4-enopyranosyluronic acid)-2-acetamido-2-deoxy-D-glucose | Paracoccidioides brasiliensis |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.6.4 | chondroitin sulfate + H2O | in chondroitin sulfate or keratan sulfate | Paracoccidioides brasiliensis | chondroitin + sulfate | - |
? | |
| 4.2.2.1 | hyaluronan | from umbilical cord | Paracoccidioides brasiliensis | 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine | - |
? | |
| 4.2.2.1 | hyaluronan | enzyme might be involved in the pathogenicity of the bacterium causing paracocidiodomycosis | Paracoccidioides brasiliensis | 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.2.2.1 | hyaluronidase | - |
Paracoccidioides brasiliensis |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.1.6.4 | 27 | - |
assay at | Paracoccidioides brasiliensis |
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Release 2023.1 (January 2023)
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