EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.21.41 | production of the CCP1-CCP2-SP, the CCP2-SP and the SP fragments in Escherichia coli | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.4.21.41 | S654A | mutant without autoactivation | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.21.41 | additional information | - |
additional information | KM-values of the C1r fragments with benzyloxycarbonyl-Lys-thiobenzyl ester or benzyloxycarbonyl-Gly-Arg-thiobenzyl ester as substrate | Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.4.21.41 | additional information | - |
molecular weight of the CCP1-CCP2-SP fragments | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.41 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.41 | benzyloxycarbonyl-Gly-Arg-thiobenzyl ester + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.21.41 | benzyloxycarbonyl-Lys-thiobenzyl ester + H2O | - |
Homo sapiens | benzyloxycarbonyl-Lys + phenylmethanethiol | - |
? | |
3.4.21.41 | complement component C1s + H2O | - |
Homo sapiens | complement component C1sbar | - |
? | |
3.4.21.41 | additional information | the ability of autoactivation of C1r and C1s cleavage activity is an inherent property of the SP domain | Homo sapiens | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.4.21.41 | dimer | deletion of CCP1 domain from CCP1-CCP2-SP fragment results in the loss of the dimeric structure. Dimerization of C1r is not a prerequisite for autoactivation | Homo sapiens |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.4.21.41 | additional information | - |
melting transition of SP fragment is 47.5°C, melting point of the CCP2-SP fragment is 55.4°C, the CCP1-CCP2-SP fragment shows an unfolding transition at 57.5°C | Homo sapiens |