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Literature summary extracted from

  • Saha, N.; Das, L.; Dutta, S.
    Types of carbamyl phosphate synthetases and subcellular localization of urea cycle and related enzymes in air-breathing walking catfish, Clarias batrachus (1999), J. Exp. Zool., 283, 121-130.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.3.4.16 additional information not: UTP Clarias batrachus
6.3.4.16 N-acetyl-L-glutamate
-
 Clarias batrachus
6.3.5.5 N-acetyl-L-glutamate only CPS III Clarias batrachus

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.5.5 UMP only CPS II Clarias batrachus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.5.5 0.46
-
 L-glutamine pH 7.5, 30°C Clarias batrachus
6.3.5.5 2.2
-
 ammonia pH 7.5, 30°C Clarias batrachus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.3.4.16 mitochondrion
-
 Clarias batrachus 5739
-
6.3.4.16 mitochondrion
-
 Heteropneustes fossilis 5739
-
6.3.5.5 cytosol CPS II Clarias batrachus 5829
-
6.3.5.5 mitochondrion CPS III Clarias batrachus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.4.16 ATP + NH3 + CO2 + H2O Clarias batrachus first step of the both the urea cycle and pyrimidine nucleotide biosynthesis patways ADP + phosphate + carbamoyl phosphate
-
 ?
6.3.5.5 2 ATP + L-Gln + HCO3- Clarias batrachus enzyme is a key enzyme in the pyrimidine nucleotide and arginine biosynthetic pathways 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.16 Clarias batrachus
-
-
-
6.3.4.16 Heteropneustes fossilis
-
-
-
6.3.5.5 Clarias batrachus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.5.5 recombinant wild-type and mutant enzymes Clarias batrachus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.16 ATP + NH3 + CO2 + H2O
-
 Heteropneustes fossilis ADP + phosphate + carbamoyl phosphate
-
 ir
6.3.4.16 ATP + NH3 + CO2 + H2O first step of the both the urea cycle and pyrimidine nucleotide biosynthesis patways Clarias batrachus ADP + phosphate + carbamoyl phosphate
-
 ?
6.3.4.16 ATP + NH4+ + CO2 + H2O
-
 Clarias batrachus ADP + phosphate + carbamoyl phosphate
-
 ?
6.3.5.5 2 ATP + L-Gln + HCO3-
-
 Clarias batrachus 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
 ?
6.3.5.5 2 ATP + L-Gln + HCO3- enzyme is a key enzyme in the pyrimidine nucleotide and arginine biosynthetic pathways Clarias batrachus 2 ADP + phosphate + L-Glu + carbamoyl phosphate
-
 ?
6.3.5.5 2 ATP + NH4+ + HCO3-
-
 Clarias batrachus 2 ADP + phosphate + carbamoyl phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.4.16 CPS I-like (ammonia- and N-acetyl-L-glutamate-dependent)
-
 Clarias batrachus
6.3.4.16 CPS I-like (ammonia- and N-acetyl-L-glutamate-dependent)
-
 Heteropneustes fossilis
6.3.5.5 CPS II (glutamine-dependent)
-
 Clarias batrachus
6.3.5.5 CPS III (glutamine- and N-acetyl-L-glutamine-dependent)
-
 Clarias batrachus