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Literature summary extracted from

  • Kaushal, G.P.; Shah, S.V.
    The new kids on the block: ADAMTSs, potentially multifunctional metalloproteinases of the ADAM family (2000), J. Clin. Invest., 105, 1335-1337.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.B11 additional information knock-out mutant shows a phenotype with reduced growth and body weight, as well as pathological changes in the kidney structure, obstructive fibrosis, disrupted capillary networks in the adrenal gland, and hypoplastic or atrophic papillae Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.B11 extracellular secretion Mus musculus
-
-
3.4.24.B11 membrane associated Mus musculus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.B11 Zn2+ dependent on, metalloproteinase, consensus sequence HEXXH Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B11 additional information Mus musculus enzyme plays a role in cell-cell and cell-matrix interactions, in cell adhesion and growth factor signaling ?
-
 ?
3.4.24.B11 proteins + H2O Mus musculus
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B11 Mus musculus
-
 enzyme belongs to the subfamily of adamalysins which is part of the superfamily of zinc-dependent proteases
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.B11 proteolytic modification enzyme is synthesized as an inactive proform, proteolytical processing of a conserved cysteine residue in its prodomain Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.B11 colonic cancer cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B11 additional information enzyme plays a role in cell-cell and cell-matrix interactions, in cell adhesion and growth factor signaling Mus musculus ?
-
 ?
3.4.24.B11 proteins + H2O
-
 Mus musculus peptides
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.24.B11 More enzyme is a multidomain protease possessing a prodomain, a cysteine-rich domain, an EGF-like domain, a transmembrane domain, and a cytoplasmic tail Mus musculus

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B11 a disintegrin and metalloproteinase with thrombospondin motifs 1
-
 Mus musculus
3.4.24.B11 ADAMTS-1
-
 Mus musculus
3.4.24.B11 M12.222 Merops-ID Mus musculus