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Literature summary extracted from

  • Serban, M.; Tanaseanu, C.; Kosaka, T.; Vidulescu, C.; Stoian, I.; Marta, D.S.; Tanaseanu, S.; Moldoveanu, E.
    Significance of platelet-activating factor acetylhydrolase in patients with non-insulin-dependent (type 2) diabetes mellitus (2002), J. Cell. Mol. Med., 6, 643-647.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.1.1.47 diagnostics the plasma enzyme is an important risk marker for endothelial dysfunction in patients with non-insulin dependent diabetes mellitus Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O Homo sapiens enzyme plays an important role in inflammatory diseases and artherosclerosis, and is involved in non-insulin dependent diabetes mellitus, the level of free, LDL- and/or HDL-associated enzyme is important, overview 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.47 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.1.47 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate hydrolysis and inactivation of the lipid mediator platelet-activating factor PAF and/or oxidized phospholipids Homo sapiens
a

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.47 additional information
-
 activity of free, LDL-, and HDL-associated enzyme in healthy and diabetic persons Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.47 1-myristoyl-2-(4-nitrophenyl succinyl)phosphatidylcholine + H2O artificial substrate Homo sapiens 1-myristoyl-phosphatidylcholine + 4-nitrophenyl succinate 4-nitrophenyl succinate spontaneously degrades and liberates 4-nitrophenol ?
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor Homo sapiens 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O enzyme plays an important role in inflammatory diseases and artherosclerosis, and is involved in non-insulin dependent diabetes mellitus, the level of free, LDL- and/or HDL-associated enzyme is important, overview Homo sapiens 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.47 lipoprotein-associated phospholipase A2
-
 Homo sapiens
3.1.1.47 PAF-AH
-
 Homo sapiens
3.1.1.47 plasma platelet - activating factor - acetylhydrolase
-
 Homo sapiens