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Literature summary extracted from

  • Ko, Y.G.; Kang, Y.S.; Kim, E.K.; Park, S.G.; Kim, S.
    Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis (2000), J. Cell Biol., 149, 567-574.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.1.1.10 polymerase I required by the nucleolar located enzyme Homo sapiens
6.1.1.10 rRNA required by the nucleolar located enzyme Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.1.1.10 DNA sequence determination and analysis, expression in Escherichia coli BL21(DE3) of the wild-type enzyme as His-tagged enzyme Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.10 actinomycin D inhibits the nucleolar located enzyme due to dependence on polymerase I Homo sapiens
6.1.1.10 alpha-Amanitin inhibits the nucleolar located enzyme due to dependence on polymerase I Homo sapiens
6.1.1.10 cisplatin inhibits the nucleolar located enzyme due to dependence on polymerase I Homo sapiens
6.1.1.10 RNase inhibits the nucleolar located enzyme due to dependence on rRNA Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.1.1.10 cytoplasm
-
 Homo sapiens 5737
-
6.1.1.10 additional information no enzyme in quiescent cells Homo sapiens
-
-
6.1.1.10 nucleolus translocation from the cytoplasm is triggered by insulin, epidermal growth factor, translocation by a proliferation signal, the enzyme is part of the multi-aminoacyl-tRNA synthetase complex in the nucleolus Homo sapiens 5730
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.10 ATP + L-methionine + tRNAMet Homo sapiens the nucleolar located enzyme is related to rRNA synthesis, the cytoplasmic enzyme is involved in protein biosynthesis AMP + diphosphate + L-methionyl-tRNAMet
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.10 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.1.1.10 fibroblast of foreskin Homo sapiens
-
6.1.1.10 HeLa cell
-
 Homo sapiens
-
6.1.1.10 Hep-G2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.10 ATP + L-methionine + tRNAMet
-
 Homo sapiens AMP + diphosphate + L-methionyl-tRNAMet
-
 ?
6.1.1.10 ATP + L-methionine + tRNAMet the nucleolar located enzyme is related to rRNA synthesis, the cytoplasmic enzyme is involved in protein biosynthesis Homo sapiens AMP + diphosphate + L-methionyl-tRNAMet
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.10 Methionine translase
-
 Homo sapiens
6.1.1.10 Methionine--tRNA ligase
-
 Homo sapiens
6.1.1.10 Methionyl tRNA synthetase
-
 Homo sapiens
6.1.1.10 Methionyl-transfer ribonucleate synthetase
-
 Homo sapiens
6.1.1.10 Methionyl-transfer ribonucleic acid synthetase
-
 Homo sapiens
6.1.1.10 Methionyl-transfer RNA synthetase
-
 Homo sapiens
6.1.1.10 MetRS
-
 Homo sapiens
6.1.1.10 Synthetase, methionyl-transfer ribonucleate
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.10 ATP
-
 Homo sapiens