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Literature summary extracted from

  • Ju, S.; Shaltiel, G.; Shamir, A.; Agam, G.; Greenberg, M.L.
    Human 1D-myo-inositol 3-phosphate synthase is functional in yeast (2004), J. Biol. Chem., 279, 21759-21765.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
5.5.1.4 NH4+ 5 mM, 5fold increase in activity Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.5.1.4 expression in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.5.1.4 Valproate slight inhibition Homo sapiens
5.5.1.4 Zn2+ 1 mM, 5fold decrease in activity Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.5.1.4 0.008
-
 NAD+
-
 Homo sapiens
5.5.1.4 0.57
-
 glucose 6-phosphate
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
5.5.1.4 Ca2+ 10 mM, 2fold stimulation Homo sapiens
5.5.1.4 K+ 10 mM, 5fold stimulation Homo sapiens
5.5.1.4 Mg2+ 1-10 mM, 2-3fold stimulation Homo sapiens
5.5.1.4 Mn2+ 1-10 mM, 2-3fold stimulation Homo sapiens
5.5.1.4 Na+ 10 mM, 2fold stimulation Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.5.1.4 D-glucose 6-phosphate Homo sapiens rate-limiting step for de novo inositol biosynthesis 1D-myo-inositol 3-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.5.1.4 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.5.1.4 recombinant enzyme Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.5.1.4 D-glucose 6-phosphate
-
 Homo sapiens 1D-myo-inositol 3-phosphate
-
 ?
5.5.1.4 D-glucose 6-phosphate rate-limiting step for de novo inositol biosynthesis Homo sapiens 1D-myo-inositol 3-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.5.1.4 MIP synthase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
5.5.1.4 37
-
-
 Homo sapiens

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
5.5.1.4 45
-
 20 min, stable up to Homo sapiens
5.5.1.4 60
-
 20 min, approximately 60% loss of activity Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5.1.4 8
-
 at 37°C Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
5.5.1.4 NAD+
-
 Homo sapiens