EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.1.2.3 | sitting drop vapor diffusion method, co-crystallized in the presence of substrate with BW1540 and BW2315 | Homo sapiens |
3.5.4.10 | in complex with transformylase inhibitors BW1540 and BW2315 | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.2.3 | BW1540 | sulfamido-bridged 5,8-dideazafolate analogue | Homo sapiens | |
2.1.2.3 | BW2315 | sulfamido-bridged 5,8-dideazafolate analogue | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazole-4-carboxamide | Homo sapiens | penultimate step of the purine de novo synthesis pathway | tetrahydrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazole-4-carboxamide | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.2.3 | Homo sapiens | P31939 | - |
- |
3.5.4.10 | Homo sapiens | P31939 | bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazole-4-carboxamide | - |
Homo sapiens | tetrahydrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazole-4-carboxamide | - |
? | |
2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazole-4-carboxamide | penultimate step of the purine de novo synthesis pathway | Homo sapiens | tetrahydrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazole-4-carboxamide | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.1.2.3 | dimer | crystal structure analysis, monomer contains two functionally independent domains transformylase and cyclohydrolase activities | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.2.3 | AICAR transformylase/inosine monophosphate cyclohydrolase | bifunctional enzyme catalyzing the last two steps of the purine de novo synthesis pathway | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.1.2.3 | 10-formyltetrahydrofolate | - |
Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.2.3 | 0.000006 | - |
BW2315 | - |
Homo sapiens | |
2.1.2.3 | 0.000008 | - |
BW1540 | - |
Homo sapiens |