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Literature summary extracted from

  • Sinha, S.C.; Chaudhuri, B.N.; Burgner, J.W.; Yakovleva, G.; Davisson, V.J.; Smith, J.L.
    Crystal structure of imidazole glycerol-phosphate dehydratase: Duplication of an unusual fold (2004), J. Biol. Chem., 279, 15491-15498.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.2.1.19 trimeric form without Mn2+, hanging drop vapor diffusion method Cryptococcus neoformans

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.1.19 Mg2+ metalloprotein, transition metals induce aggregation and are required for catalysis, 1 equivalent of Mn2+ per subunit induces the formation of 24-mers from the trimeric enzyme Cryptococcus neoformans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.19 additional information Cryptococcus neoformans sixth step in histidine biosynthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.19 Cryptococcus neoformans P0CO22
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.1.19
-
 Cryptococcus neoformans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.19 D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate removal of a non-acidic hydrogen atom in the dehydration reaction Cryptococcus neoformans 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O
-
 ?
4.2.1.19 additional information sixth step in histidine biosynthesis Cryptococcus neoformans ?
-
 ?

Subunits

EC Number Subunits Comment Organism
4.2.1.19 multimer 1 equivalent of Mn2+ per subunit induces the formation of 24-mers from the trimeric enzyme Cryptococcus neoformans
4.2.1.19 trimer 1 equivalent of Mn2+ per subunit induces the formation of 24-mers from the trimeric enzyme Cryptococcus neoformans