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Literature summary extracted from

  • Van Meeteren, L.A.; Frederiks, F.; Giepmans, B.N.G.; Pedrosa, M.F.F.; Billington, S.J.; Jost, B.H.; Tambourgi, D.V.; Moolenaar, W.H.
    Spider and bacterial sphingomyelinases D target cellular lysophosphatidic acid receptors by hydrolyzing lysophosphatidylcholine (2004), J. Biol. Chem., 279, 10833-10836.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.41 EDTA strong Corynebacterium pseudotuberculosis
3.1.4.41 EDTA strong Loxosceles laeta

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.41 0.022
-
 1-O-hexadecylglycero-3-phosphocholine pH 7.4, 37°C Corynebacterium pseudotuberculosis
3.1.4.41 0.044
-
 1-O-hexadecylglycero-3-phosphocholine pH 7.4, 37°C Loxosceles laeta

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.41 Mg2+ absolute requirement Corynebacterium pseudotuberculosis
3.1.4.41 Mg2+ absolute requirement Loxosceles laeta

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.41 additional information Corynebacterium pseudotuberculosis physiological effects of enzyme ?
-
 ?
3.1.4.41 additional information Loxosceles laeta physiological effects of enzyme ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.41 Corynebacterium pseudotuberculosis
-
-
-
3.1.4.41 Loxosceles laeta
-
 spider
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.41 1-O-hexadecylglycero-3-phosphocholine + H2O i.e. lyso-platelet-activating factor Corynebacterium pseudotuberculosis choline + 1-O-hexadecylglycero-3-phosphate
-
 ?
3.1.4.41 1-O-hexadecylglycero-3-phosphocholine + H2O i.e. lyso-platelet-activating factor Loxosceles laeta choline + 1-O-hexadecylglycero-3-phosphate
-
 ?
3.1.4.41 lysophosphatidylcholine + H2O
-
 Loxosceles laeta lysophosphatidic acid + choline
-
 ?
3.1.4.41 lysophosphatidylcholine + H2O albumin-bound Corynebacterium pseudotuberculosis lysophosphatidic acid + choline
-
 ?
3.1.4.41 additional information no substrate: sphingosylphosphorylcholine Corynebacterium pseudotuberculosis ?
-
 ?
3.1.4.41 additional information no substrate: sphingosylphosphorylcholine Loxosceles laeta ?
-
 ?
3.1.4.41 additional information physiological effects of enzyme Corynebacterium pseudotuberculosis ?
-
 ?
3.1.4.41 additional information physiological effects of enzyme Loxosceles laeta ?
-
 ?
3.1.4.41 sphingomyelin + H2O
-
 Corynebacterium pseudotuberculosis choline + ceramide phosphate
-
 ?
3.1.4.41 sphingomyelin + H2O
-
 Loxosceles laeta choline + ceramide phosphate
-
 ?