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Literature summary extracted from

  • Goel, M.S.; Diamond, S.L.
    Neutrophil cathepsin G promotes prothrombinase and fibrin formation under flow conditions by activating fibrinogen-adherent platelets (2003), J. Biol. Chem., 278, 9458-9463.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.20 phosphocholine phospholipid vesicles containing phosphatidyl-L-serine and phosphocholine are required for enzyme-mediated thrombin production in platelet-free plasma, potentially due to protection of lipid bound enzyme from inhibition Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.20 benzyloxycarbonyl-Gly-Leu-Phe-chloromethyl ketone
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.20 additional information Homo sapiens the enzyme can directly alter platelet function and/or participate in coagulation cascade reactions on the platelet or neutrophil surface to enhance fibrin formation, coagulation pathway overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.20 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.20 neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.20 additional information the enzyme can directly alter platelet function and/or participate in coagulation cascade reactions on the platelet or neutrophil surface to enhance fibrin formation, coagulation pathway overview Homo sapiens ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.20 37
-
 assay at Homo sapiens