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Literature summary extracted from

  • Fleming, J.V.; Wang, T.C.
    The production of 53-55-kDa isoforms is not required for rat L-histidine decarboxylase dctivity (2003), J. Biol. Chem., 278, 686-694.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.22 gastrin increase of steady-state levels of 6 HDC isoforms Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.22 expression in COS-7 cells Rattus norvegicus
4.1.1.22 expression of cDNA in COS-7 cells Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.22 L-histidine Rattus norvegicus
-
 histamine + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.22 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
4.1.1.22 proteolytic modification post-translational processing of 74000 Da HDC is required for activity, carboxyl-terminal processing generates an active 55000 Da isoform and additional isoforms with molecular weights higher than 55000 Da Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.22 L-histidine
-
 Rattus norvegicus histamine + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
4.1.1.22 More five HDC isoforms of 63000 Da, 54000 Da, 48000 Da, 40000 Da and 36000 Da, that derive from the 74000 Da full-length primary translation isoform Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
4.1.1.22 HDC
-
 Rattus norvegicus