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Literature summary extracted from

  • Song, E.S.; Juliano, M.A.; Juliano, L.; Hersh, L.B.
    Substrate activation of insulin-degrading enzyme (insulysin). A potential target for drug development (2003), J. Biol. Chem., 278, 49789-49794.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.56 amyloid beta-peptide 1-40
-
 Rattus norvegicus
3.4.24.56 beta-endorphin
-
 Rattus norvegicus
3.4.24.56 bradykinin
-
 Rattus norvegicus
3.4.24.56 dynorphin A-17
-
 Rattus norvegicus
3.4.24.56 dynorphin B-13
-
 Rattus norvegicus
3.4.24.56 dynorphin B-9 2.5fold increase in amyloid beta peptide hydrolysis Rattus norvegicus
3.4.24.56 Insulin B chain
-
 Rattus norvegicus

Application

EC Number Application Comment Organism
3.4.24.56 medicine IDE represents a target for the development of a new class of drugs for the treatment of Alzheimer's disease that lowers amyloid beta-peptide levels by increasing ist rate of catabolism Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.56 recombinant enzyme produced in Sf9 cells Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.56 dynorphin B-9 inhibitory with insulin as substrate Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.56 Zn2+ zinc metallopeptidase Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.56 amyloid beta peptide 1-40 + H2O Rattus norvegicus physiolgical substrate ?
-
 ?
3.4.24.56 insulin + H2O Rattus norvegicus physiolgical substrate ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.56 Rattus norvegicus
-
 rat
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.56 2-amino-benzoyl-GGFLRKAGQ-ethylenediamine-2,4-dinitrophenyl + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 2-amino-benzoyl-GGFLRKHGQ-ethylenediamine-2,4-dinitrophenyl + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 2-amino-benzoyl-GGFLRKMGQ-ethylenediamine-2,4-dinitrophenyl + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 amyloid beta peptide + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 amyloid beta peptide 1-40 + H2O physiolgical substrate Rattus norvegicus ?
-
 ?
3.4.24.56 beta-endorphin + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 bradykinin + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 dynorphin A-17 + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 dynorphin B-13 + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 dynorphin B-9 + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 insulin + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 insulin + H2O physiolgical substrate Rattus norvegicus ?
-
 ?
3.4.24.56 Insulin B-chain + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 additional information gamma-endorphin, Leu-Arg, and Leu-enkephalin are not significantly cleaved Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.56 IDE
-
 Rattus norvegicus
3.4.24.56 Insulin-degrading enzyme
-
 Rattus norvegicus