EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.B10 | PACSIN3 | protein that interacts with the enzyme via its proline-rich region, amino acid residues 829-840, at the cytoplasmic domain, interaction is necessary for the upregulation of proHB-EGF shedding | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.24.B10 | expression in a yeast two-hybrid system as GT-tagged enzyme | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.B10 | protein + H2O | Homo sapiens | key enzyme in the ectodomain shedding of membrane-anchored heparin-binding epidermal growth factor, i.e. proHB-EGF, leading to epidermal growth factor-like receptor transactivation | peptides | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.B10 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.B10 | protein + H2O | - |
Homo sapiens | peptides | - |
? | |
3.4.24.B10 | protein + H2O | key enzyme in the ectodomain shedding of membrane-anchored heparin-binding epidermal growth factor, i.e. proHB-EGF, leading to epidermal growth factor-like receptor transactivation | Homo sapiens | peptides | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.24.B10 | a disintegrin and metalloprotease 12 | - |
Homo sapiens |
3.4.24.B10 | ADAM12 | - |
Homo sapiens |
3.4.24.B10 | ADAM12/meltrin alpha | - |
Homo sapiens |
3.4.24.B10 | M12.212 | Merops-ID | Homo sapiens |
3.4.24.B10 | meltrin alpha | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.4.24.B10 | 37 | - |
assay at | Homo sapiens |