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Literature summary extracted from

  • Holden, H.M.; Rayment, I.; Thoden, J.B.
    Structure and function of enzymes of the Leloir pathway for galactose metabolism (2003), J. Biol. Chem., 278, 43885-43888.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
5.1.3.2 Y299C mutation results in a loss of epimerase activity with regard to UDPgalactose by almost 5fold, it results in a gain of activity against UDP-GalNAc by more than 230fold Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.1.3.2 additional information Homo sapiens impairement of the enzyme results in galacosemia III that can lead to symptoms ranging from benign to severe ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
5.1.3.2 Escherichia coli
-
-
-
5.1.3.2 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.1.3.2 additional information impairement of the enzyme results in galacosemia III that can lead to symptoms ranging from benign to severe Homo sapiens ?
-
 ?
5.1.3.2 UDP-GlcNAc
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 Homo sapiens UDP-GalNAc
-
 r
5.1.3.2 UDP-GlcNAc wild-type enzyme shows no interconversion of UDP-GlcNAc and UDP-GalNAc, mutation Y299C results in a gain of activity against UDP-GalNAc by more than 230fold Escherichia coli UDP-GalNAc
-
 r