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Literature summary extracted from

  • Kalafatis, M.; Beck, D.O.; Mann, K.G.
    Structural requirements for expression of factor Va activity (2003), J. Biol. Chem., 278, 33550-33561.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.6 D13R
-
 Homo sapiens
3.4.21.6 factor Va peptide factor Va amino acid residues 697-709, i.e. D13R, competitive inhibition of prothrombinase activity with respect to prothrombin, inhibition mechanism Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.6 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.21.6 selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin scutelarin has similar specificity Homo sapiens
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.6 prothrombin + H2O
-
 Homo sapiens thrombin + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.6 factor Xa
-
 Homo sapiens
3.4.21.6 More the enzyme belongs to the peptidase family S1, i.e. trypsin family Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
3.4.21.6 Factor VIIa human plasma factor V activated by thrombin, residues 1-709 and 1546-2196, required for catalytic activity in the prothrombinase complex activating prothrombin to thrombin Homo sapiens
3.4.21.6 factor VNN factor V cleaved by the venom of the snake Naja nigricollis nigricollis at Asp697, Asp1509, and Asp1514, 2 fragments of MW 100 and 80 kDa, 7% clotting activity compared to factor VIIa Homo sapiens
3.4.21.6 factor VNN/IIa factor VNN cleaved by alpha-thrombin at Arg1545, 48% clotting activity compared to factor VIIa Homo sapiens
3.4.21.6 factor VNN/RVV factor VNN cleaved by Russell's viper venom at Arg1545, 48% clotting activity compared to factor VIIa Homo sapiens
3.4.21.6 factor VRVV factor V cleaved by Russell's viper venom at Arg1018 and Arg1545, 2 fragments of MW 74 and 150 kDa, 102% clotting activity compared to factor VIIa Homo sapiens
3.4.21.6 additional information dissociation constants for binding to factor Xa for the factor Va variants at pH 7.4 and in presence of phospholipid vesicles containing phosphocholine and phosphatidylserine and Ca2+ Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.21.6 0.0064
-
 D13R
-
 Homo sapiens