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Literature summary extracted from

  • Anguera, M.C.; Suh, J.R.; Ghandour, H.; Nasrallah, I.M.; Selhub, J.; Stover, P.J.
    Methenyltetrahydrofolate synthetase regulates folate turnover and accumulation (2003), J. Biol. Chem., 278, 29856-29862.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.3.3.2 5-formyltetrahydrofolate polyglutamate induced recombinant enzyme expression in cancer cell cultures, increasing effect with increasing chain length Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.3.2 expression in MCF-7 mammary adenocarcinoma cell line and in SH-SY5Y neuroblastoma cell line Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.3.2 additional information
-
additional information kinetics Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.3.3.2 cytosol
-
Mus musculus 5829
-
6.3.3.2 cytosol
-
Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.3.2 ATP + 5-formyltetrahydrofolate Mus musculus
-
ADP + phosphate + 5,10-methenyltetrahydrofolate
-
?
6.3.3.2 ATP + 5-formyltetrahydrofolate Homo sapiens enzyme plays an important role in one-carbon metabolism, overview about folate catabolism ADP + phosphate + 5,10-methenyltetrahydrofolate
-
ir

Organism

EC Number Organism UniProt Comment Textmining
6.3.3.2 Homo sapiens
-
-
-
6.3.3.2 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.3.2 brain low enzyme expression Mus musculus
-
6.3.3.2 embryo moderate enzyme expression Mus musculus
-
6.3.3.2 heart low enzyme expression Mus musculus
-
6.3.3.2 kidney moderate enzyme expression Mus musculus
-
6.3.3.2 liver highest enzyme expression Mus musculus
-
6.3.3.2 lung low enzyme expression Mus musculus
-
6.3.3.2 additional information tissue specific expression Homo sapiens
-
6.3.3.2 ovary moderate enzyme expression Mus musculus
-
6.3.3.2 spleen low enzyme expression Mus musculus
-
6.3.3.2 testis low enzyme expression Mus musculus
-
6.3.3.2 thymus moderate enzyme expression Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.3.3.2 additional information
-
activity of recombinantly expressed enzyme in different cell cultures Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.3.2 ATP + 5-formyltetrahydrofolate
-
Mus musculus ADP + phosphate + 5,10-methenyltetrahydrofolate
-
?
6.3.3.2 ATP + 5-formyltetrahydrofolate enzyme prefers the polyglutamate forms of the substrate compared to the monoglutamate form Homo sapiens ADP + phosphate + 5,10-methenyltetrahydrofolate
-
ir
6.3.3.2 ATP + 5-formyltetrahydrofolate enzyme plays an important role in one-carbon metabolism, overview about folate catabolism Homo sapiens ADP + phosphate + 5,10-methenyltetrahydrofolate
-
ir

Synonyms

EC Number Synonyms Comment Organism
6.3.3.2 Methenyltetrahydrofolate synthetase
-
Mus musculus
6.3.3.2 Methenyltetrahydrofolate synthetase
-
Homo sapiens
6.3.3.2 MTHFS
-
Mus musculus
6.3.3.2 MTHFS
-
Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3.3.2 6
-
assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.3.2 ATP
-
Mus musculus