EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
6.3.3.2 | 5-formyltetrahydrofolate polyglutamate | induced recombinant enzyme expression in cancer cell cultures, increasing effect with increasing chain length | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
6.3.3.2 | expression in MCF-7 mammary adenocarcinoma cell line and in SH-SY5Y neuroblastoma cell line | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
6.3.3.2 | additional information | - |
additional information | kinetics | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
6.3.3.2 | cytosol | - |
Mus musculus | 5829 | - |
6.3.3.2 | cytosol | - |
Homo sapiens | 5829 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.3.3.2 | ATP + 5-formyltetrahydrofolate | Mus musculus | - |
ADP + phosphate + 5,10-methenyltetrahydrofolate | - |
? | |
6.3.3.2 | ATP + 5-formyltetrahydrofolate | Homo sapiens | enzyme plays an important role in one-carbon metabolism, overview about folate catabolism | ADP + phosphate + 5,10-methenyltetrahydrofolate | - |
ir |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
6.3.3.2 | Homo sapiens | - |
- |
- |
6.3.3.2 | Mus musculus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
6.3.3.2 | brain | low enzyme expression | Mus musculus | - |
6.3.3.2 | embryo | moderate enzyme expression | Mus musculus | - |
6.3.3.2 | heart | low enzyme expression | Mus musculus | - |
6.3.3.2 | kidney | moderate enzyme expression | Mus musculus | - |
6.3.3.2 | liver | highest enzyme expression | Mus musculus | - |
6.3.3.2 | lung | low enzyme expression | Mus musculus | - |
6.3.3.2 | additional information | tissue specific expression | Homo sapiens | - |
6.3.3.2 | ovary | moderate enzyme expression | Mus musculus | - |
6.3.3.2 | spleen | low enzyme expression | Mus musculus | - |
6.3.3.2 | testis | low enzyme expression | Mus musculus | - |
6.3.3.2 | thymus | moderate enzyme expression | Mus musculus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
6.3.3.2 | additional information | - |
activity of recombinantly expressed enzyme in different cell cultures | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.3.3.2 | ATP + 5-formyltetrahydrofolate | - |
Mus musculus | ADP + phosphate + 5,10-methenyltetrahydrofolate | - |
? | |
6.3.3.2 | ATP + 5-formyltetrahydrofolate | enzyme prefers the polyglutamate forms of the substrate compared to the monoglutamate form | Homo sapiens | ADP + phosphate + 5,10-methenyltetrahydrofolate | - |
ir | |
6.3.3.2 | ATP + 5-formyltetrahydrofolate | enzyme plays an important role in one-carbon metabolism, overview about folate catabolism | Homo sapiens | ADP + phosphate + 5,10-methenyltetrahydrofolate | - |
ir |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
6.3.3.2 | Methenyltetrahydrofolate synthetase | - |
Mus musculus |
6.3.3.2 | Methenyltetrahydrofolate synthetase | - |
Homo sapiens |
6.3.3.2 | MTHFS | - |
Mus musculus |
6.3.3.2 | MTHFS | - |
Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
6.3.3.2 | 6 | - |
assay at | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
6.3.3.2 | ATP | - |
Mus musculus |