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Literature summary extracted from

  • Javanbakht, H.; Halwani, R.; Cen, S.; Saadatmand, J.; Musier-Forsyth, K.; Gottlinger, H.; Kleiman, L.
    The interaction between HIV-1 Gag and human lysyl-tRNA synthetase during viral assembly (2003), J. Biol. Chem., 278, 27644-27651.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.1.1.6 additional information specific binding to HIV Gag protein, thereby signaling and mediation of selective recognition and packaging of tRNALys isoacceptors as well as the enzyme itself into HIV particles, the Gag protein alone is sufficient for the incorporation, determination and mapping of interaction regions Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.6 ATP + lysine + tRNALys Homo sapiens
-
 AMP + L-lysyl-tRNALys + diphosphate
-
 ?
6.1.1.6 additional information Homo sapiens the enzyme signals and mediates the selective recognition and packaging of tRNALys isoacceptors into HIV particles, the human enzyme is selectively packaged into virions of the human immunodeficiency virus during virus assembly, along with and independent of its cognate tRNALys isoacceptors, packaging is mediated by the viral protein Gag, which alone is sufficient for the incorporation, determination of interaction regions ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.6 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
6.1.1.6 proteolytic modification the enzyme is N-terminally cleaved during incorporation into HIV particles Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.6 ATP + lysine + tRNALys
-
 Homo sapiens AMP + L-lysyl-tRNALys + diphosphate
-
 ?
6.1.1.6 additional information the enzyme signals and mediates the selective recognition and packaging of tRNALys isoacceptors into HIV particles, the human enzyme is selectively packaged into virions of the human immunodeficiency virus during virus assembly, along with and independent of its cognate tRNALys isoacceptors, packaging is mediated by the viral protein Gag, which alone is sufficient for the incorporation, determination of interaction regions Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.6 L-Lysine-transfer RNA ligase
-
 Homo sapiens
6.1.1.6 Lysine translase
-
 Homo sapiens
6.1.1.6 Lysine--tRNA ligase
-
 Homo sapiens
6.1.1.6 Lysine-tRNA synthetase
-
 Homo sapiens
6.1.1.6 LysRS
-
 Homo sapiens
6.1.1.6 Lysyl-transfer ribonucleate synthetase
-
 Homo sapiens
6.1.1.6 Lysyl-transfer RNA synthetase
-
 Homo sapiens
6.1.1.6 Lysyl-tRNA synthetase
-
 Homo sapiens
6.1.1.6 Synthetase, lysyl-transfer ribonucleate
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.6 ATP
-
 Homo sapiens