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Literature summary extracted from

  • Luque, A.; Carpizo, D.R.; Iruela-Arispe, M.L.
    ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165 (2003), J. Biol. Chem., 278, 23656-23665.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B11 expression of full-length wild-type enzyme in human embryonic kidney cell line 293T, expression of C-terminal region of the enzyme, corresponding to amino acid residues 549-951, in breast tumor derived cell line T47D Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.B11 additional information introduction of a KpnI site at the 5'-end, expression in carcinoma cell line T47D Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.B11 Zn2+ metalloprotease Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B11 additional information Homo sapiens vascular endothelial growth factor 165 and vascular endothelial growth factor 165 receptor tyrosine kinase are no substrates for proteolytic cleavage, but the enzyme blocks endothelial vascularization by inhibiting the necessary phosphorylation of the receptor, interaction with heparin via the first TSP1 domain at the C-terminal part, enzyme shows an antiangiogenic effect, the enzyme is able to shed proteins from the surface of the endothelium ?
-
 ?
3.4.24.B11 proteins + H2O Homo sapiens
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B11 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.B11 recombinant enzyme from cell line 293T Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B11 additional information vascular endothelial growth factor 165 and vascular endothelial growth factor 165 receptor tyrosine kinase are no substrates for proteolytic cleavage, but the enzyme blocks endothelial vascularization by inhibiting the necessary phosphorylation of the receptor Homo sapiens ?
-
 ?
3.4.24.B11 additional information vascular endothelial growth factor 165 and vascular endothelial growth factor 165 receptor tyrosine kinase are no substrates for proteolytic cleavage, but the enzyme blocks endothelial vascularization by inhibiting the necessary phosphorylation of the receptor, interaction with heparin via the first TSP1 domain at the C-terminal part, enzyme shows an antiangiogenic effect, the enzyme is able to shed proteins from the surface of the endothelium Homo sapiens ?
-
 ?
3.4.24.B11 proteins + H2O
-
 Homo sapiens peptides
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B11 ADAMTS1
-
 Homo sapiens
3.4.24.B11 M12.222 Merops-ID Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.B11 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.24.B11 7.6
-
 assay at Homo sapiens