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Literature summary extracted from

  • Kysela, B.; Doherty, A.J.; Chovanec, M.; Stiff, T.; Ameer-Beg, S.M.; Vojnovic, B.; Girard, P.M.; Jeggo, P.A.
    Ku stimulation of DNA ligase IV-dependent ligation requires inward movement along the DNA molecule (2003), J. Biol. Chem., 278, 22466-22474.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.5.1.1 coexpression of DNA ligase IV-XRCC4 complex in Sf9 insect cells Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Homo sapiens DNA ligase IV-XRCC4 complex functions in DNA non-homologous-end joining, the main pathwy for double-strand repair in mammalian cells AMP + diphosphate + (deoxyribonucleotide)m+n
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 ?

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.1 Homo sapiens
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-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.5.1.1 recombinant DNA ligase IV-XRCC4 complex, metal-chelate Talon affinity resin, Mono Q Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m ligation activity of DNA ligase IV-XRCC4 complex depends upon substrate length, efficient ligation of a 445 bp substrate, little ligation of a 53 bp substrate Homo sapiens AMP + diphosphate + (deoxyribonucleotide)m+n
-
 ?
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m DNA ligase IV-XRCC4 complex functions in DNA non-homologous-end joining, the main pathwy for double-strand repair in mammalian cells Homo sapiens AMP + diphosphate + (deoxyribonucleotide)m+n
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.5.1.1 DNA ligase IV
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 Homo sapiens