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Literature summary extracted from

  • Szeltner, Z.; Rea, D.; Renner, V.; Fulop, V.; Polgar, L.
    Electrostatic effects and binding determinants in the catalysis of prolyl oligopeptidase. Site specific mutagenesis at the oxyanion binding site (2002), J. Biol. Chem., 277, 42613-42622.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.4.21.26 wild-type enzyme, mutant enzyme Y473F, mutant enzyme Y473F + benzyloxcarbonyl-Pro-prolinal and mutant enzyme S554A + succinyl-Gly-Pro-OH Sus scrofa

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.26 Y473F catalysis by the wild-type enzyme exhibits positive activation entropy. In contrast the activation entropy for the mutant enzyme is negative Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.26 Sus scrofa P23687
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.26 brain
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.26 2-aminobenzoyl-Gly-Phe-Gly-Pro-Phe-Gly-Phe(NO2)-Ala-NH2 + H2O
-
 Sus scrofa 2-aminobenzoyl-Gly-Phe-Gly-Pro + Phe-Gly-Phe(NO2)-Ala-NH2
-
 ?
3.4.21.26 benzyloxycarbonyl-Gly-Pro-beta-naphthylamide + H2O
-
 Sus scrofa benzyloxycarbonyl-Gly-Pro + beta-naphthylamine
-
 ?