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Literature summary extracted from

  • Ranalli, T.A.; Tom, S.; Bambara, R.A.
    AP endonuclease 1 coordinates flap endonuclease 1 and DNA ligase I activity in long patch base excision repair (2002), J. Biol. Chem., 277, 41715-41724.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.5.1.1 apurine/apyrimidinic endonuclease I stimulation of DNA ligase activity, inhibition if the DNA ligase I substrate has a tetrahydrofuran residue on the 5'-downstream primer of a nick, simulating a reduced abasic site Homo sapiens
6.5.1.1 proliferating cell nuclear antigen
-
 Homo sapiens
6.5.1.1 replication protein
-
 Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.5.1.1
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.5.1.1 apurine/apyrimidinic endonuclease I inhibition if the DNA ligase I substrate has a tetrahydrofuran residue on the 5'-downstream primer of a nick, simulating a reduced abasic site Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Homo sapiens
-
 AMP + diphosphate + (deoxyribonucleotide)m+n
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.1 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.5.1.1 recombinant DNA ligase I Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
 Homo sapiens AMP + diphosphate + (deoxyribonucleotide)m+n
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.5.1.1 DNA ligase I
-
 Homo sapiens