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Literature summary extracted from

  • Park, H.I.; Turk, B.E.; Gerkema, F.E.; Cantley, L.C.; Sang, Q.X.
    Peptide substrate specificities and protein cleavage sites of human endometase/matrilysin-2/matrix metalloproteinase-26 (2002), J. Biol. Chem., 277, 35168-35175.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.B7 (3R)-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
-
 Homo sapiens
3.4.24.B7 (3S)-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
-
 Homo sapiens
3.4.24.B7 4-Aminobenzoyl-Gly-Pro-D-Leu-D-Ala-NHOH
-
 Homo sapiens
3.4.24.B7 N-[(2R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan i.e. GM6001 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.B7 Zn2+ a zinc metalloproteinase Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B7 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.B7 proteolytic modification two of the major autolytic sites are Leu49–/-Thr50 and Ala75–/-Leu76, which still left the cysteine switch sequence intact Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B7 (7-methoxycoumarin)-4-yl-acetyl-Pro-Leu-Ala-Nva-(N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-Ala-Arg-NH2 + H2O among the fluorescent peptide substrates analyzed, 7-amido-4-methylcoumaryl-Pro-Leu-Ala-Nva-(N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-Ala-Arg-NH2 displays the highest specificity constant Homo sapiens (7-methoxycoumarin)-4-yl-acetyl-Pro-Leu-Ala + Nva-(N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-Ala-Arg-NH2
-
 ?
3.4.24.B7 alpha1-proteinase inhibitor + H2O MMP-26 cleaves Phe352–Leu353 and Pro357–Met358 in the reactive loop of alpha1-proteinase inhibitor, probably rendering the substrate inactive Homo sapiens ?
-
 ?
3.4.24.B7 insulin-like growth factor-binding protein-1 + H2O cleaves His140–Val141 in insulin-like growth factor-binding protein-1, probably rendering the substrate inactive Homo sapiens ?
-
 ?
3.4.24.B7 peptide + H2O the optimal cleavage motifs for MMP-26 are Lys-Pro-Ile(Leu)-Ser-/-Leu(Met)-Ile(Thr)-Ser(Ala)-Ser. The strongest preference is observed at the P1' and P2 sites where hydrophobic residues are favored. Proline is preferred at P3, and serine is preferred at P1 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B7 MMP-26
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.24.B7 0.00000036
-
 N-[(2R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan
-
 Homo sapiens
3.4.24.B7 0.0000015
-
 (3R)-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
-
 Homo sapiens
3.4.24.B7 0.0000029
-
 4-Aminobenzoyl-Gly-Pro-D-Leu-D-Ala-NHOH
-
 Homo sapiens
3.4.24.B7 0.00006
-
 (3S)-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.24.B7 0.0034
-
-
 Homo sapiens 4-Aminobenzoyl-Gly-Pro-D-Leu-D-Ala-NHOH