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Literature summary extracted from

  • Fukuoka, S.; Ishiguro, K.; Yanagihara, K.; Tanabe, A.; Egashira, Y.; Sanada, H.; Shibata, K.
    Identification and expression of a cDNA encoding human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD). A key enzyme for the tryptophan-niacine pathway and "quinolinate hypothesis" (2002), J. Biol. Chem., 277, 35162-35167.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.1.1.45 medicine quinolinate, non-enzymatically derived from 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate is a potent endogenous excitotoxin of neuronal cells, whose elevation in brain is implicated in the pathogenesis of various neurodegenerative disorders, ACMSD is the only known enzyme that can process ACMS to a benign catabolite and thus prevent the accumulation of quinolinate Sus scrofa
4.1.1.45 medicine quinolinate, non-enzymatically derived from 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate is a potent endogenous excitotoxin of neuronal cells, whose elevation in brain is implicated in the pathogenesis of various neurodegenerative disorders, ACMSD is the only known enzyme that can process ACMS to a benign catabolite and thus prevent the accumulation of quinolinate Mus musculus
4.1.1.45 medicine quinolinate, non-enzymatically derived from 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate is a potent endogenous excitotoxin of neuronal cells, whose elevation in brain is implicated in the pathogenesis of various neurodegenerative disorders, ACMSD is the only known enzyme that can process ACMS to a benign catabolite and thus prevent the accumulation of quinolinate Rattus norvegicus
4.1.1.45 medicine quinolinate, non-enzymatically derived from 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate is a potent endogenous excitotoxin of neuronal cells, whose elevation in brain is implicated in the pathogenesis of various neurodegenerative disorders, ACMSD is the only known enzyme that can process ACMS to a benign catabolite and thus prevent the accumulation of quinolinate Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.45 cDNA cloning, expressed in COS7 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.45 p-chloromercuribenzoate
-
Homo sapiens
4.1.1.45 p-chloromercuribenzoate
-
Mus musculus
4.1.1.45 p-chloromercuribenzoate
-
Rattus norvegicus
4.1.1.45 p-chloromercuribenzoate
-
Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate Sus scrofa tryptophan-niacine pathway 2-aminomuconate-6-semialdehyde + CO2
-
?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate Mus musculus tryptophan-niacine pathway 2-aminomuconate-6-semialdehyde + CO2
-
?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate Rattus norvegicus tryptophan-niacine pathway 2-aminomuconate-6-semialdehyde + CO2
-
?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate Homo sapiens tryptophan-niacine pathway 2-aminomuconate-6-semialdehyde + CO2
-
?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate Mus musculus ICR tryptophan-niacine pathway 2-aminomuconate-6-semialdehyde + CO2
-
?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.45 Homo sapiens Q8TDX5 human
-
4.1.1.45 Mus musculus Q8R519 mouse, ICR strain
-
4.1.1.45 Mus musculus ICR Q8R519 mouse, ICR strain
-
4.1.1.45 Rattus norvegicus Q8R5M5 rat
-
4.1.1.45 Sus scrofa
-
pig
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.45
-
Sus scrofa
4.1.1.45
-
Mus musculus
4.1.1.45
-
Rattus norvegicus
4.1.1.45 partial Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
-
Sus scrofa 2-aminomuconate-6-semialdehyde + CO2
-
?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
-
Mus musculus 2-aminomuconate-6-semialdehyde + CO2
-
?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
-
Rattus norvegicus 2-aminomuconate-6-semialdehyde + CO2
-
?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
-
Homo sapiens 2-aminomuconate-6-semialdehyde + CO2
-
?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate tryptophan-niacine pathway Sus scrofa 2-aminomuconate-6-semialdehyde + CO2
-
?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate tryptophan-niacine pathway Mus musculus 2-aminomuconate-6-semialdehyde + CO2
-
?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate tryptophan-niacine pathway Rattus norvegicus 2-aminomuconate-6-semialdehyde + CO2
-
?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate tryptophan-niacine pathway Homo sapiens 2-aminomuconate-6-semialdehyde + CO2
-
?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
-
Mus musculus ICR 2-aminomuconate-6-semialdehyde + CO2
-
?
4.1.1.45 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate tryptophan-niacine pathway Mus musculus ICR 2-aminomuconate-6-semialdehyde + CO2
-
?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.45 ACMSD
-
Sus scrofa
4.1.1.45 ACMSD
-
Mus musculus
4.1.1.45 ACMSD
-
Rattus norvegicus
4.1.1.45 ACMSD
-
Homo sapiens