EC Number | Application | Comment | Organism |
---|---|---|---|
4.1.1.45 | medicine | quinolinate, non-enzymatically derived from 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate is a potent endogenous excitotoxin of neuronal cells, whose elevation in brain is implicated in the pathogenesis of various neurodegenerative disorders, ACMSD is the only known enzyme that can process ACMS to a benign catabolite and thus prevent the accumulation of quinolinate | Sus scrofa |
4.1.1.45 | medicine | quinolinate, non-enzymatically derived from 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate is a potent endogenous excitotoxin of neuronal cells, whose elevation in brain is implicated in the pathogenesis of various neurodegenerative disorders, ACMSD is the only known enzyme that can process ACMS to a benign catabolite and thus prevent the accumulation of quinolinate | Mus musculus |
4.1.1.45 | medicine | quinolinate, non-enzymatically derived from 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate is a potent endogenous excitotoxin of neuronal cells, whose elevation in brain is implicated in the pathogenesis of various neurodegenerative disorders, ACMSD is the only known enzyme that can process ACMS to a benign catabolite and thus prevent the accumulation of quinolinate | Rattus norvegicus |
4.1.1.45 | medicine | quinolinate, non-enzymatically derived from 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate is a potent endogenous excitotoxin of neuronal cells, whose elevation in brain is implicated in the pathogenesis of various neurodegenerative disorders, ACMSD is the only known enzyme that can process ACMS to a benign catabolite and thus prevent the accumulation of quinolinate | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
4.1.1.45 | cDNA cloning, expressed in COS7 cells | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.1.1.45 | p-chloromercuribenzoate | - |
Homo sapiens | |
4.1.1.45 | p-chloromercuribenzoate | - |
Mus musculus | |
4.1.1.45 | p-chloromercuribenzoate | - |
Rattus norvegicus | |
4.1.1.45 | p-chloromercuribenzoate | - |
Sus scrofa |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.1.45 | 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | Sus scrofa | tryptophan-niacine pathway | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
4.1.1.45 | 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | Mus musculus | tryptophan-niacine pathway | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
4.1.1.45 | 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | Rattus norvegicus | tryptophan-niacine pathway | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
4.1.1.45 | 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | Homo sapiens | tryptophan-niacine pathway | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
4.1.1.45 | 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | Mus musculus ICR | tryptophan-niacine pathway | 2-aminomuconate-6-semialdehyde + CO2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.1.1.45 | Homo sapiens | Q8TDX5 | human | - |
4.1.1.45 | Mus musculus | Q8R519 | mouse, ICR strain | - |
4.1.1.45 | Mus musculus ICR | Q8R519 | mouse, ICR strain | - |
4.1.1.45 | Rattus norvegicus | Q8R5M5 | rat | - |
4.1.1.45 | Sus scrofa | - |
pig | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
4.1.1.45 | - |
Sus scrofa |
4.1.1.45 | - |
Mus musculus |
4.1.1.45 | - |
Rattus norvegicus |
4.1.1.45 | partial | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.1.45 | 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | - |
Sus scrofa | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
4.1.1.45 | 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | - |
Mus musculus | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
4.1.1.45 | 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | - |
Rattus norvegicus | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
4.1.1.45 | 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | - |
Homo sapiens | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
4.1.1.45 | 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | tryptophan-niacine pathway | Sus scrofa | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
4.1.1.45 | 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | tryptophan-niacine pathway | Mus musculus | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
4.1.1.45 | 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | tryptophan-niacine pathway | Rattus norvegicus | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
4.1.1.45 | 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | tryptophan-niacine pathway | Homo sapiens | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
4.1.1.45 | 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | - |
Mus musculus ICR | 2-aminomuconate-6-semialdehyde + CO2 | - |
? | |
4.1.1.45 | 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate | tryptophan-niacine pathway | Mus musculus ICR | 2-aminomuconate-6-semialdehyde + CO2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.1.1.45 | ACMSD | - |
Sus scrofa |
4.1.1.45 | ACMSD | - |
Mus musculus |
4.1.1.45 | ACMSD | - |
Rattus norvegicus |
4.1.1.45 | ACMSD | - |
Homo sapiens |