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Literature summary extracted from

  • D'Angelo, M.A.; Montagna, A.E.; Sanguineti, S.; Torres, H.N.; Flawia, M.M.
    A Novel Calcium-stimulated Adenylyl Cyclase from Trypanosoma cruzi, Which Interacts with the Structural Flagellar Protein Paraflagellar Rod (2002), J. Biol. Chem., 277, 35025-35034.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.6.1.1 expression in Saccharomyces cerevisiae Trypanosoma cruzi

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.1 2'-deoxyadenosine 3'-monophosphate 0.1 mM, 50% inhibition Trypanosoma cruzi
4.6.1.1 Zn2+ 0.007 mM, 50% inhibition Trypanosoma cruzi

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.6.1.1 0.4
-
ATP recombinant TczAC Trypanosoma cruzi

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.6.1.1 membrane
-
Trypanosoma cruzi 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.6.1.1 Ca2+ 1 mM, 2-3fold stimulation, Km of 0.22 mM Trypanosoma cruzi
4.6.1.1 Mg2+
-
Trypanosoma cruzi
4.6.1.1 Mn2+ 8-10fold higher activity than in the presence of Mg2+ Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.1 ATP Trypanosoma cruzi
-
3',5'-cyclic AMP + diphosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.1 Trypanosoma cruzi O77079
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.6.1.1 0.000094
-
recombinant TczAC activity in membrane extracts Trypanosoma cruzi

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.1 ATP
-
Trypanosoma cruzi 3',5'-cyclic AMP + diphosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.1 adenylyl cyclase
-
Trypanosoma cruzi
4.6.1.1 TczAC
-
Trypanosoma cruzi