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Literature summary extracted from

  • Lorey, S.; Faust, J.; Mrestani-Klaus, C.; Kaehne, T.; Ansorge, S.; Neubert, K.; Buehling, F.
    Transcellular proteolysis demonstrated by novel cell surface-associated substrates of dipeptidyl peptidase IV (CD26) (2002), J. Biol. Chem., 277, 33170-33177.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.14.5 overexpression in CHO cells Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.14.5 Nepsilon-nitrobenzyloxycarbonyl-Lys-thiazolide specific Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.14.5 0.00058
-
N-(Ala-Pro)-N'-6-(3,4-dichloromaleimidyl)-hexanoyl-rhodamine 110 pH 7.2, 30°C Sus scrofa
3.4.14.5 0.0011
-
N-(Gly-Pro)-N'-(4-chloromethyl)benzoyl-rhodamine 110 pH 7.2, 30°C Sus scrofa
3.4.14.5 0.0013
-
Gly-L-Pro-rhodamine 110-(N-pentyl)maleimide pH 7.2, 30°C Sus scrofa
3.4.14.5 0.0015
-
N-(Gly-Pro)-N'-(5-bromopentanoyl)-rhodamine 110 pH 7.2, 30°C Sus scrofa
3.4.14.5 0.0027
-
N-(Gly-Pro)-N'-4-(maleimidyl)butanoyl-rhodamine 110 pH 7.2, 30°C Sus scrofa
3.4.14.5 0.0038
-
N-(Gly-Pro)-N'-(4-chlorobutanoyl)-rhodamine 110 pH 7.2, 30°C Sus scrofa
3.4.14.5 0.0038
-
N-(Gly-Pro)-N'-(5-chloropentanoyl)-rhodamine 110 pH 7.2, 30°C Sus scrofa
3.4.14.5 0.0062
-
N-(Gly-Pro)-N'-chloroacetyl-rhodamine 110 pH 7.2, 30°C Sus scrofa
3.4.14.5 0.0174
-
N-(Gly-Pro)-N'-acetyl-rhodamine 110 pH 7.2, 30°C Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.14.5 membrane cell surface-associated Sus scrofa 16020
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.14.5 Sus scrofa
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.14.5 release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline enzyme is an ectopeptidase Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.14.5 kidney
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.14.5 0.000025
-
U937 cells, substrate Gly-Pro-4-nitroanilide Sus scrofa
3.4.14.5 51.9
-
purified enzyme, substrate Gly-Pro-4-nitroanilide Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.14.5 Gly-L-Pro-rhodamine 110-(N-pentyl)maleimide + H2O
-
Sus scrofa Gly-L-Pro + rhodamine 110-(N-pentyl)maleimide
-
?
3.4.14.5 Gly-Pro-4-nitroanilide + H2O
-
Sus scrofa Gly-Pro + 4-nitroaniline
-
?
3.4.14.5 additional information larger compounds are cleaved with lower efficiency, importance of steric effects Sus scrofa ?
-
?
3.4.14.5 N-(Ala-Pro)-N'-6-(3,4-dichloromaleimidyl)-hexanoyl-rhodamine 110 + H2O fluorogenic substrate, membrane-anchored on the cell surface in a cell-based assay Sus scrofa Ala-Pro + N-6-(3,4-dichloromaleimidyl)-hexanoyl-rhodamine 110
-
?
3.4.14.5 N-(Gly-Pro)-N'-(4-chlorobutanoyl)-rhodamine 110 + H2O fluorogenic substrate, membrane-anchored on the cell surface in a cell-based assay Sus scrofa Gly-Pro + N-(4-chlorobutanoyl)-rhodamine 110
-
?
3.4.14.5 N-(Gly-Pro)-N'-(4-chloromethyl)benzoyl-rhodamine 110 + H2O fluorogenic substrate, membrane-anchored on the cell surface in a cell-based assay Sus scrofa Gly-Pro + N-(4-chloromethyl)benzoyl-rhodamine 110
-
?
3.4.14.5 N-(Gly-Pro)-N'-(5-bromopentanoyl)-rhodamine 110 + H2O fluorogenic substrate, membrane-anchored on the cell surface in a cell-based assay Sus scrofa Gly-Pro + N-(5-bromopentanoyl)-rhodamine 110
-
?
3.4.14.5 N-(Gly-Pro)-N'-(5-chloropentanoyl)-rhodamine 110 + H2O fluorogenic substrate, membrane-anchored on the cell surface in a cell-based assay Sus scrofa Gly-Pro + N-(5-chloropentanoyl)-rhodamine 110
-
?
3.4.14.5 N-(Gly-Pro)-N'-4-(maleimidyl)butanoyl-rhodamine 110 + H2O fluorogenic substrate, membrane-anchored on the cell surface in a cell-based assay Sus scrofa Gly-Pro + N-4-(maleimidyl)butanoyl-rhodamine 110
-
?
3.4.14.5 N-(Gly-Pro)-N'-6-(maleimidyl)hexanoyl-rhodamine 110 + H2O fluorogenic substrate, membrane-anchored on the cell surface in a cell-based assay Sus scrofa Gly-Pro + N-6-(maleimidyl)hexanoyl-rhodamine 110
-
?
3.4.14.5 N-(Gly-Pro)-N'-acetyl-rhodamine 110 + H2O fluorogenic substrate, membrane-anchored on the cell surface in a cell-based assay Sus scrofa Gly-Pro + N-acetyl-rhodamine 110
-
?
3.4.14.5 N-(Gly-Pro)-N'-chloroacetyl-rhodamine 110 + H2O fluorogenic substrate, membrane-anchored on the cell surface in a cell-based assay Sus scrofa Gly-Pro + N-chloroacetyl-rhodamine 110
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.14.5 CD26
-
Sus scrofa
3.4.14.5 dipeptidyl peptidase IV
-
Sus scrofa
3.4.14.5 DP IV
-
Sus scrofa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.14.5 30 37 assay at Sus scrofa

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.14.5 0.55
-
N-(Ala-Pro)-N'-6-(3,4-dichloromaleimidyl)-hexanoyl-rhodamine 110 pH 7.2, 30°C Sus scrofa
3.4.14.5 0.7
-
N-(Gly-Pro)-N'-(4-chlorobutanoyl)-rhodamine 110 pH 7.2, 30°C Sus scrofa
3.4.14.5 1.6
-
N-(Gly-Pro)-N'-chloroacetyl-rhodamine 110 pH 7.2, 30°C Sus scrofa
3.4.14.5 3.22
-
N-(Gly-Pro)-N'-(5-bromopentanoyl)-rhodamine 110 pH 7.2, 30°C Sus scrofa
3.4.14.5 3.4
-
N-(Gly-Pro)-N'-(4-chloromethyl)benzoyl-rhodamine 110 pH 7.2, 30°C Sus scrofa
3.4.14.5 8
-
N-(Gly-Pro)-N'-4-(maleimidyl)butanoyl-rhodamine 110 pH 7.2, 30°C Sus scrofa
3.4.14.5 8
-
N-(Gly-Pro)-N'-(5-chloropentanoyl)-rhodamine 110 pH 7.2, 30°C Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.14.5 7.2
-
assay at Sus scrofa