EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.6 | nematode anticoagulant protein c2 | i.e. NAPc2, binds either to factor X or factor Xa, tight binding, competitive, binds to a macromolecular substrate binding, exosite site of human prothrombinase complex, recombinantly expressed in Pichia pastoris and purified, inhibition kinetics | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.21.6 | additional information | - |
additional information | kinetics, dissociation constants | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.21.6 | extracellular | - |
Homo sapiens | - |
- |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.6 | Ca2+ | required as part of thr prothrombinase enzyme complex | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.6 | prothrombin + H2O | Homo sapiens | - |
thrombin + ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.6 | Homo sapiens | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
3.4.21.6 | proteolytic modification | processing of factor X to factor Xa can be performed with Russell's viper venom | Homo sapiens |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.21.6 | native wild-type from plasma | Homo sapiens |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
3.4.21.6 | selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin | scutelarin has similar specificity | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.21.6 | plasma | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.6 | methoxycarbonyl-D-cyclohexylglycyl-glycyl-L-ariginine-4-nitroanilide + H2O | i.e. Spectrozyme fXa, SpfXa | Homo sapiens | methoxycarbonyl-D-cyclohexylglycyl-glycyl-L-ariginine + 4-nitroaniline | - |
? | |
3.4.21.6 | additional information | enzyme possesses a macromolecular substrate binding site, exosite | Homo sapiens | ? | - |
? | |
3.4.21.6 | Prethrombin 2 + H2O | - |
Homo sapiens | ? | - |
? | |
3.4.21.6 | prothrombin + H2O | - |
Homo sapiens | thrombin + ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.4.21.6 | More | enzyme is complexed in the prothrombinase complex with factor Va, Ca2+, and phospholipids or membrane, respectively | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.21.6 | factor Xa | - |
Homo sapiens |
3.4.21.6 | More | the enzyme belongs to the peptidase family S1, i.e. trypsin family | Homo sapiens |
3.4.21.6 | Xa | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.4.21.6 | 25 | - |
assay at | Homo sapiens |