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Literature summary extracted from

  • Malfait, A.M.; Liu, R.Q.; Ijiri, K.; Komiya, S.; Tortorella, M.D.
    Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage (2002), J. Biol. Chem., 277, 22201-22208.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.24.B12 medicine potential target for treatment of osteoarthritis Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.B12 aggrecanase inhibitor BB-16 prevents aggrecan degradation in osteoarthritic cartilage Homo sapiens
3.4.24.B12 additional information no inhibition by matrix metalloprotease inhibitor XS309 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.B12 70000
-
 x * 70000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B12 aggrecan + H2O Homo sapiens cleavage site is Glu373-Ala374 ?
-
 ?
3.4.24.B12 proteins + H2O Homo sapiens
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B12 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.B12 glycoprotein several glycosylation sites Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.B12 cartilage osteoarthritic, protein and mRNA Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B12 aggrecan + H2O cleavage site is Glu373-Ala374 Homo sapiens ?
-
 ?
3.4.24.B12 aggrecan + H2O cleavage site is Glu373-Ala374, other cleavage sites are Glu1545-Gly1546, Glu1819-Ala1820, and Glu1919-Leu1920 Homo sapiens ?
-
 ?
3.4.24.B12 proteins + H2O
-
 Homo sapiens peptides
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.24.B12 ? x * 70000, SDS-PAGE Homo sapiens
3.4.24.B12 More a 30 kDa C-terminal truncated form, epitope mapping Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B12 ADAM-TS5
-
 Homo sapiens
3.4.24.B12 aggrecanase-2
-
 Homo sapiens
3.4.24.B12 M12.225 Merops-ID Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.B12 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.24.B12 7.5
-
 assay at Homo sapiens