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Literature summary extracted from

  • Ranalli, T.A.; DeMott, M.S.; Bambara, R.A.
    Mechanism underlying replication protein A stimulation of DNA ligase I (2002), J. Biol. Chem., 277, 1719-1727.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.5.1.1 replication protein A approx. 15fold stimulation of DNA ligase I Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.5.1.1
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.5.1.1 0.0000034
-
 ATP 30°C Homo sapiens
6.5.1.1 0.0000049
-
 ATP 30°C, in the presence of 0.0000125 mM replication protein A Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Homo sapiens
-
 AMP + diphosphate + (deoxyribonucleotide)m+n
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.1 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.5.1.1 recombinant DNA ligase I Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
 Homo sapiens AMP + diphosphate + (deoxyribonucleotide)m+n
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.5.1.1 DNA ligase I
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
6.5.1.1 0.0026
-
 ATP 30°C Homo sapiens
6.5.1.1 0.012
-
 ATP 30°C, in the presence of 0.0000125 mM replication protein A Homo sapiens