Literature summary extracted from

Levert, K.L.; Waldrop, G.L.; Stephens, J.M.
A biotin analog inhibits acetyl-CoA carboxylase activity and adipogenesis (2002), J. Biol. Chem., 277, 16347-16350.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
6.4.1.2	chloroacetylated biotin derivative	80% inhibition	Mus musculus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
6.4.1.2	ATP + acetyl-CoA + HCO3-	Mus musculus	key enzyme of fatty acid biosynthesis	ADP + phosphate + malonyl-CoA	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
6.4.1.2	Mus musculus	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6.4.1.2	ATP + acetyl-CoA + HCO3-	-	Mus musculus	ADP + phosphate + malonyl-CoA	-	?
6.4.1.2	ATP + acetyl-CoA + HCO3-	key enzyme of fatty acid biosynthesis	Mus musculus	ADP + phosphate + malonyl-CoA	-	?

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
6.4.1.2	biotin	enzyme-bound	Mus musculus

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Release 2023.1 (January 2023)