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Literature summary extracted from

  • Rossi, V.; Cseh, S.; Bally, I.; Thielens, N.M.; Jensenius, J.C.; Arlaud, G.J.
    Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2 (2001), J. Biol. Chem., 276, 40880-40887.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.B7 mature protein and truncated fragments Homo sapiens
3.4.21.104 mature protein and truncated fragments Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.B7 C1 inhibitor abolishes activity at a 1:1 inhibitor:protease concentration Homo sapiens
3.4.21.104 C1 inhibitor abolishes activity at a 1:1 inhibitor:protease concentration Homo sapiens
3.4.21.104 additional information no inhibitor: alpha-2-macroglobulin Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.21.B7 0.18
-
 Nalpha-benzoyl-L-arginine ethyl ester pH 7.4, 30°C Homo sapiens
3.4.21.B7 0.31
-
 N-carboxybenzyloxyglycine-L-arginine thiobenzyl ester pH 7.4, 30°C Homo sapiens
3.4.21.104 2.8
-
 p-tosyl-L-arginine methyl ester pH 7.4, 30°C Homo sapiens
3.4.21.104 4.4
-
 Nalpha-benzoyl-L-arginine ethyl ester pH 7.4, 30°C Homo sapiens
3.4.21.104 6.5
-
 Complement component C2 pH 7.4, 30°C Homo sapiens
3.4.21.104 6.7
-
 N-acetylglycine-L-lysine methyl ester pH 7.4, 30°C Homo sapiens
3.4.21.104 40
-
 N-carboxybenzoylglycine-L-arginine thiobenzyl ester pH 7.4, 30°C Homo sapiens
3.4.21.104 74
-
 Complement component C4 pH 7.4, 30°C Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.B7 32000
-
 1 * 32000 + 1 * 34000, SDS-PAGE, reducing conditions Homo sapiens
3.4.21.B7 34000
-
 1 * 32000 + 1 * 34000, SDS-PAGE, reducing conditions Homo sapiens
3.4.21.B7 50000
-
 SDS-PAGE, non-reducing conditions Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.B7 additional information Homo sapiens involved in innate immunity ?
-
 ?
3.4.21.B7 Protein + H2O Homo sapiens
-
 ?
-
 ?
3.4.21.104 Protein + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B7 Homo sapiens
-
-
-
3.4.21.104 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.B7 partial Homo sapiens
3.4.21.104 mature protein and truncated fragments Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B7 complement component C2 + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.B7 complement component C3 + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.B7 additional information no activity with complement C4 Homo sapiens ?
-
 ?
3.4.21.B7 additional information involved in innate immunity Homo sapiens ?
-
 ?
3.4.21.B7 N-carboxybenzyloxyglycine-L-arginine thiobenzyl ester + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.B7 Nalpha-benzoyl-L-arginine ethyl ester + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.B7 Protein + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.104 complement component C2 + H2O
-
 Homo sapiens complement component C2a + complement component C2b
-
 ?
3.4.21.104 complement component C2 + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.104 complement component C3 + H2O very weak substrate Homo sapiens ?
-
 ?
3.4.21.104 complement component C4 + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.104 complement component C4 + H2O
-
 Homo sapiens complement component C4-alpha + complement component C4-alpha'
-
 ?
3.4.21.104 N-acetylglycine-L-lysine methyl ester + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.104 N-carboxybenzoylglycine-L-arginine thiobenzyl ester + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.104 Nalpha-benzoyl-L-arginine ethyl ester + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.104 p-tosyl-L-arginine methyl ester + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.104 Protein + H2O
-
 Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.B7 dimer 1 * 32000 + 1 * 34000, SDS-PAGE, reducing conditions Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B7 MASP-1
-
 Homo sapiens
3.4.21.104 MASP-2
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.21.B7 0.35
-
 Nalpha-benzoyl-L-arginine ethyl ester pH 7.4, 30°C Homo sapiens
3.4.21.B7 1.23
-
 N-carboxybenzyloxyglycine-L-arginine thiobenzyl ester pH 7.4, 30°C Homo sapiens
3.4.21.B7 6.08
-
 N-carboxybenzyloxyglycine-L-arginine thiobenzyl ester pH 7.4, 30°C Homo sapiens
3.4.21.104 2.2
-
 Complement component C4 pH 7.4, 30°C Homo sapiens
3.4.21.104 2.4
-
 Nalpha-benzoyl-L-arginine ethyl ester pH 7.4, 30°C Homo sapiens
3.4.21.104 4.9
-
 Complement component C2 pH 7.4, 30°C Homo sapiens
3.4.21.104 7.1
-
 p-tosyl-L-arginine methyl ester pH 7.4, 30°C Homo sapiens
3.4.21.104 12.7
-
 N-carboxybenzoylglycine-L-arginine thiobenzyl ester pH 7.4, 30°C Homo sapiens
3.4.21.104 133
-
 N-acetylglycine-L-lysine methyl ester pH 7.4, 30°C Homo sapiens