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Literature summary extracted from

  • Lewin, T.M.; Kim, J.H.; Granger, D.A.; Vance, J.E.; Coleman, R.A.
    Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different subcellular membranes in rat liver and can be inhibited independently (2001), J. Biol. Chem., 276, 24674-24679.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.2.1.3 NEM ACS4 Rattus norvegicus
6.2.1.3 triacsin competitive inhibitor of both ACS1 and ACS4 Rattus norvegicus
6.2.1.3 troglitazone ACS4 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.3 cytosol ACS1 Rattus norvegicus 5829
-
6.2.1.3 endoplasmic reticulum ACS1 Rattus norvegicus 5783
-
6.2.1.3 membrane mitochondria-associated membrane, ACS1, ACS4 Rattus norvegicus 16020
-
6.2.1.3 mitochondrion mitochondrial membrane, ACS5. ACS1 is not detected in mitochondria Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.3 additional information Rattus norvegicus ACS1, ACS4 and ACS5 are regulated independently by fasting and refeeding. Fasting rats for 48 h results in a decrease in ACS4 protein and an increase in ACS5. ACS1 and ACS4 may be functionally channeled to specific metabolic pathways though different ACS isoforms in unique subcellular locations ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.3 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.3 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.3 ATP + palmitate + CoA
-
 Rattus norvegicus AMP + diphosphate + palmitoyl-CoA
-
 ?
6.2.1.3 additional information ACS1, ACS4 and ACS5 are regulated independently by fasting and refeeding. Fasting rats for 48 h results in a decrease in ACS4 protein and an increase in ACS5. ACS1 and ACS4 may be functionally channeled to specific metabolic pathways though different ACS isoforms in unique subcellular locations Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.3 ACS1
-
 Rattus norvegicus
6.2.1.3 ACS4
-
 Rattus norvegicus
6.2.1.3 ACS5
-
 Rattus norvegicus