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Literature summary extracted from

  • Kang, Q.; Cao, Y.; Zolkiewska, A.
    Direct interaction between the cytoplasmic tail of ADAM 12 and the Src homology 3 domain of p85alpha activates phosphatidylinositol 3-kinase in C2C12 cells (2001), J. Biol. Chem., 276, 24466-24472.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B10 expression as GFP-pleckstrin homology domain fusion protein in C2C12 cells, targeted to the plasma membrane by a myristoylation motif Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.B10 additional information construction of deletion mutants Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.B10 additional information metalloprotease Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B10 protein + H2O Mus musculus
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B10 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.B10 skeletal muscle gene expression Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B10 additional information enzyme provides docking sites for the Src homology 3 domain of p85alpha and thus activates PI 3-kinase by mediating its recruitment to the membrane Mus musculus ?
-
 ?
3.4.24.B10 protein + H2O
-
 Mus musculus peptides
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B10 a disintegrin and metalloprotease-12
-
 Mus musculus
3.4.24.B10 ADAM 12
-
 Mus musculus
3.4.24.B10 M12.212 Merops-ID Mus musculus