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Literature summary extracted from

  • Belkin, A.M.; Akimov, S.S.; Zaritskaya, L.S.; Ratnikov, B.I.; Deryugina, E.I.; Strongin, A.Y.
    Matrix-dependent proteolysis of surface transglutaminase by membrane-type metalloproteinase regulates cancer cell adhesion and locomotion (2001), J. Biol. Chem., 276, 18415-18422.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B5 functional expression of enzyme in HT1080 cells and U251 glioma cells, leading to enhanced levels of pro-matrix metalloprotease-2 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.B5 fibronectin protects the cell surface tissue transglutaminase against degradation by MT1 MMP Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.B5 membrane on the cell surface Homo sapiens 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.B5 42000
-
 x * 42000, MT1 MMP ectodomain, SDS-PAGE, x * 60000, MT1 MMP, active enzyme, SDS-PAGE Homo sapiens
3.4.24.B5 60000
-
 x * 42000, MT1 MMP ectodomain, SDS-PAGE, x * 60000, MT1 MMP, active enzyme, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B5 cell surface tissue transglutaminase + H2O Homo sapiens regulation of cancer cell adhesion, degradation supresses specifically cell adhesion and migration on fibronectin, but stimulates migration of cells on collagen ?
-
 ?
3.4.24.B5 protein + H2O Homo sapiens
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B5 Homo sapiens P50281 membrane-type-1, -type -2 and -type-3 matrix metalloproteases
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.B5 HT-1080 cell low expression level Homo sapiens
-
3.4.24.B5 U-251 cell low expression level Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B5 cell surface tissue transglutaminase + H2O at the leading edge of motile cancer cells, membrane-type-1, -type -2 and -type-3 matrix metalloproteases Homo sapiens 4 major and several minor cleavage products of cell surface tissue transglutaminase
-
 ?
3.4.24.B5 cell surface tissue transglutaminase + H2O regulation of cancer cell adhesion, degradation supresses specifically cell adhesion and migration on fibronectin, but stimulates migration of cells on collagen Homo sapiens ?
-
 ?
3.4.24.B5 progelatinase A + H2O substrate is activated by cleavage Homo sapiens gelatinase A + ?
-
 ?
3.4.24.B5 protein + H2O
-
 Homo sapiens peptides
-
 ?
3.4.24.B5 protein + H2O enzyme is involved in breakdown of extracellular matrix Homo sapiens peptides
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.24.B5 ? x * 42000, MT1 MMP ectodomain, SDS-PAGE, x * 60000, MT1 MMP, active enzyme, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B5 M10.015 Merops-ID Homo sapiens
3.4.24.B5 membrane-type matrix metalloproteinase
-
 Homo sapiens
3.4.24.B5 membrane-type-1 matrix metalloproteinase
-
 Homo sapiens
3.4.24.B5 membrane-type-2 matrix metalloproteinase
-
 Homo sapiens
3.4.24.B5 membrane-type-3 matrix metalloproteinase
-
 Homo sapiens
3.4.24.B5 MT MMP
-
 Homo sapiens
3.4.24.B5 MT1 MMP
-
 Homo sapiens
3.4.24.B5 MT2 MMP
-
 Homo sapiens
3.4.24.B5 MT3 MMP
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.B5 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.24.B5 7.5
-
 assay at Homo sapiens