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Literature summary extracted from

  • Bertenshaw, G.P.; Turk, B.E.; Hubbard, S.J.; Matters, G.L.; Bylander, J.E.; Crisman, J.M.; Cantley, L.C.; Bond, J.S.
    Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity (2001), J. Biol. Chem., 276, 13248-13255.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.63 Trypsin
-
 Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.18 actinonin
-
 Mus musculus
3.4.24.18 Pro-Leu-Gly-hydroxamate
-
 Mus musculus
3.4.24.63 actinonin
-
 Mus musculus
3.4.24.63 Pro-Leu-Gly-hydroxamate
-
 Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.24.18 0.116
-
 gastri-releasing peptide-(14-27) pH 7.5, 37°C Mus musculus
3.4.24.18 0.118
-
 Substance P pH 7.5, 37°C Mus musculus
3.4.24.18 0.12
-
 valosin pH 7.5, 37°C Mus musculus
3.4.24.63 0.0071
-
 gastrin pH 7.5, 37°C Mus musculus
3.4.24.63 0.0481
-
 gastri-releasing peptide-(14-27) pH 7.5, 37°C Mus musculus
3.4.24.63 0.1
-
 orcokinin pH 7.5, 37°C Mus musculus
3.4.24.63 0.211
-
 sCCK8NH2 pH 7.5, 37°C Mus musculus
3.4.24.63 0.22
-
 glucagon pH 7.5, 37°C Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.18 cell surface
-
 Mus musculus 9986
-
3.4.24.63 cell surface
-
 Mus musculus 9986
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.18 Mus musculus
-
 mouse, strain ICR and C3H/He
-
3.4.24.63 Mus musculus
-
 mouse strain, ICR and C3H/He
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.18 alpha-melanocyte stimulating hormone + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
3.4.24.18 angiotensin I + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
3.4.24.18 bombesin + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
3.4.24.18 bradykinin + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
3.4.24.18 cerulein + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
3.4.24.18 collagen I + H2O
-
 Mus musculus ?
-
 ?
3.4.24.18 Collagen IV + H2O
-
 Mus musculus ?
-
 ?
3.4.24.18 Fibronectin + H2O
-
 Mus musculus ?
-
 ?
3.4.24.18 gastri-releasing peptide-(14-27) + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
3.4.24.18 Gelatin + H2O
-
 Mus musculus ?
-
 ?
3.4.24.18 Glucagon + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
3.4.24.18 Laminin + H2O
-
 Mus musculus ?
-
 ?
3.4.24.18 luteinizing hormone releasing hormone LHRH + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
3.4.24.18 additional information orcokinin, gastrin 17, peptide YY, kinetensin, [Lys8]-vasopressin, somatostatin, kassinin, oxytocin, and alpha-neurokinin are no substrates Mus musculus ?
-
 ?
3.4.24.18 neuropeptide Y + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
3.4.24.18 neurotensin + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
3.4.24.18 parathyroid hormone fragment 13-34 + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
3.4.24.18 sCCK8NH2 + H2O peptide of the gastrointestinal tract Mus musculus L-Asp-L-Tyr(SO3)-L-Met-Gly-L-Trp-L-Met + L-Asp-L-Phe
-
 ?
3.4.24.18 Secretin + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
3.4.24.18 Substance P + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
3.4.24.18 valosin + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
3.4.24.18 Vasoactive intestinal peptide + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
3.4.24.63 alpha-MSH + H2O
-
 Mus musculus ?
-
 ?
3.4.24.63 Boc-CCK8NH2 + H2O peptide of the gastrointestinal tract Mus musculus N-tert-butyloxycarbonyl-L-Asp-L-Tyr-L-Met-Gly-L-Trp-L-Met + L-Asp-L-Phe
-
 ?
3.4.24.63 CCK4 + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
3.4.24.63 CCK5 + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
3.4.24.63 CCK6 + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
3.4.24.63 CCK7 + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
3.4.24.63 CCK8 + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
3.4.24.63 CCK8NH2 + H2O peptide of the gastrointestinal tract Mus musculus L-Asp-L-Tyr-L-Met-Gly-L-Trp-L-Met + L-Asp-L-Phe
-
 ?
3.4.24.63 cerulein + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
3.4.24.63 collagen I + H2O
-
 Mus musculus ?
-
 ?
3.4.24.63 Collagen IV + H2O
-
 Mus musculus ?
-
 ?
3.4.24.63 Fibronectin + H2O
-
 Mus musculus ?
-
 ?
3.4.24.63 gastri-releasing peptide-(14-27) + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
3.4.24.63 gastrin + H2O
-
 Mus musculus ?
-
 ?
3.4.24.63 gastrin 17 + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
3.4.24.63 Gelatin + H2O
-
 Mus musculus ?
-
 ?
3.4.24.63 Glucagon + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
3.4.24.63 Laminin + H2O
-
 Mus musculus ?
-
 ?
3.4.24.63 neuropeptide Y + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
3.4.24.63 orcokinin + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
3.4.24.63 osteopontin + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?
3.4.24.63 sCCK8NH2 + H2O peptide of the gastrointestinal tract Mus musculus L-Asp-L-Tyr(SO3)-L-Met-Gly-L-Trp-L-Met + L-Asp-L-Phe
-
 ?
3.4.24.63 Secretin + H2O peptide of the gastrointestinal tract Mus musculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.24.18 oligomer
-
 Mus musculus
3.4.24.63 oligomer
-
 Mus musculus

Synonyms

EC Number Synonyms Comment Organism
3.4.24.18 metalloprotease meprin A
-
 Mus musculus
3.4.24.63 metalloprotease meprin B
-
 Mus musculus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.24.18 11.8
-
 secretin pH 7.5, 37°C Mus musculus
3.4.24.18 17.4
-
 glucagon pH 7.5, 37°C Mus musculus
3.4.24.18 18.8
-
 valosin pH 7.5, 37°C Mus musculus
3.4.24.18 22
-
 bradykinin pH 7.5, 37°C Mus musculus
3.4.24.63 12.4
-
 gastrin pH 7.5, 37°C Mus musculus
3.4.24.63 12.6
-
 gastri-releasing peptide-(14-27) pH 7.5, 37°C Mus musculus
3.4.24.63 13.9
-
 sCCK8NH2 pH 7.5, 37°C Mus musculus
3.4.24.63 15.9
-
 glucagon pH 7.5, 37°C Mus musculus
3.4.24.63 23.4
-
 orcokinin pH 7.5, 37°C Mus musculus
3.4.24.63 26.8
-
 glucagon pH 7.5, 37°C Mus musculus