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Literature summary extracted from

  • Lee, S.L.; Dickson, R.B.; Lin, C.Y.
    Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease (2000), J. Biol. Chem., 275, 36720-36725.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.21.109 0.00381
-
 N-tert-butoxycarbonyl-gamma-benzyl-Glu-Ala-Arg-7-amido-4-methylcoumarin pH 8.5 Homo sapiens
3.4.21.109 0.00489
-
 N-tert-butoxycarbonyl-Gln-Ala-Arg 7-amido-4-methylcoumarin pH 8.5 Homo sapiens
3.4.21.109 0.0136
-
 N-tert-butoxycarbonyl-Leu-Gly-Arg-7-amido-4-methylcoumarin pH 8.5 Homo sapiens
3.4.21.109 0.0335
-
 N-tert-butoxycarbonyl-Gln-Ala-Arg 7-amido-4-methylcoumarin pH 8.5 Homo sapiens
3.4.21.109 0.0475
-
 N-tert-butoxycarbonyl-gamma-benzyl-Glu-Gly-Arg-7-amido-4-methylcoumarin pH 8.5 Homo sapiens
3.4.21.109 0.0699
-
 N-succinyl-Ala-Phe-Lys-7-amido-4-methylcoumarin pH 8.5 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.109 70000
-
 SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.109 additional information Homo sapiens initiator of matrix-degrading protein cascade, activates hepatocyte growth factor scattering factor ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.109 Homo sapiens Q9Y5Y6
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.109 milk
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.109 hepatocyte growth factor + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.109 additional information cleaves synthetic substrates with arginine or lysine as their P1 sites and prefers small side chain amino acids, such as Ala and Gly, at P2 sites Homo sapiens ?
-
 ?
3.4.21.109 additional information initiator of matrix-degrading protein cascade, activates hepatocyte growth factor scattering factor Homo sapiens ?
-
 ?
3.4.21.109 N-succinyl-Ala-Phe-Lys-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens N-succinyl-Ala-Phe-Lys + 7-amino-4-methylcoumarin
-
 ?
3.4.21.109 N-tert-butoxycarbonyl-gamma-benzyl-Glu-Ala-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens N-tert-butoxycarbonyl-gamma-benzyl-Glu-Ala-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.21.109 N-tert-butoxycarbonyl-gamma-benzyl-Glu-Gly-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens N-tert-butoxycarbonyl-gamma-benzyl-Glu-Gly-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.21.109 N-tert-butoxycarbonyl-Gln-Ala-Arg 7-amido-4-methylcoumarin + H2O
-
 Homo sapiens N-tert-butoxycarbonyl-Gln-Ala-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.21.109 N-tert-butoxycarbonyl-Leu-Gly-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens N-tert-butoxycarbonyl-Leu-Gly-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.21.109 plasminogen + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.109 pro-urokinase plasminogen activator + H2O
-
 Homo sapiens ?
-
 ?