EC Number | Application | Comment | Organism |
---|---|---|---|
3.4.24.56 | medicine | the Alzheimer's beta-amyloid peptide is degraded by the enzyme | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.24.56 | 1,10-phenanthroline | - |
Rattus norvegicus | |
3.4.24.56 | adrenocorticotropic hormone | competitive inhibition of amylin degradation | Rattus norvegicus | |
3.4.24.56 | amylin | excess amylin inhibits amylin degradation, competitive inhibition | Rattus norvegicus | |
3.4.24.56 | Aprotinin | 22.4% inhibition | Rattus norvegicus | |
3.4.24.56 | atrialnatriuretic peptide | competitive inhibition of amylin degradation | Rattus norvegicus | |
3.4.24.56 | bacitracin | - |
Rattus norvegicus | |
3.4.24.56 | EDTA | 21% inhibition; 35.7% inhibition | Rattus norvegicus | |
3.4.24.56 | glucagon | competitive inhibition of amylin degradation | Rattus norvegicus | |
3.4.24.56 | Insulin | inhibits amylin degradation, excess insulin inhibits insulin degradation | Rattus norvegicus | |
3.4.24.56 | additional information | pepstatin-A, leupeptin, and calpains are ineffective as inhibitors, no competitive inhibition with EGF or insulin C-peptide | Rattus norvegicus | |
3.4.24.56 | N-ethylmaleimide | - |
Rattus norvegicus | |
3.4.24.56 | PMSF | 14.4% inhibition | Rattus norvegicus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.4.24.56 | 110000 | - |
SDS-PAGE | Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.56 | Rattus norvegicus | - |
rat, Sprague-Dawley | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.24.56 | - |
Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.56 | amylin + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.56 | beta-amyloid peptide + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.56 | insulin + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.24.56 | additional information | EGF and insulin C-peptide are no substrates | Rattus norvegicus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.24.56 | IDE | - |
Rattus norvegicus |
3.4.24.56 | Insulin-degrading enzyme | - |
Rattus norvegicus |