Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Bennett, R.G.; Duckworth, W.C.; Hamel, F.G.
    Degradation of amylin by insulin-degrading enzyme (2000), J. Biol. Chem., 275, 36621-36625.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.24.56 medicine the Alzheimer's beta-amyloid peptide is degraded by the enzyme Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.56 1,10-phenanthroline
-
Rattus norvegicus
3.4.24.56 adrenocorticotropic hormone competitive inhibition of amylin degradation Rattus norvegicus
3.4.24.56 amylin excess amylin inhibits amylin degradation, competitive inhibition Rattus norvegicus
3.4.24.56 Aprotinin 22.4% inhibition Rattus norvegicus
3.4.24.56 atrialnatriuretic peptide competitive inhibition of amylin degradation Rattus norvegicus
3.4.24.56 bacitracin
-
Rattus norvegicus
3.4.24.56 EDTA 21% inhibition; 35.7% inhibition Rattus norvegicus
3.4.24.56 glucagon competitive inhibition of amylin degradation Rattus norvegicus
3.4.24.56 Insulin inhibits amylin degradation, excess insulin inhibits insulin degradation Rattus norvegicus
3.4.24.56 additional information pepstatin-A, leupeptin, and calpains are ineffective as inhibitors, no competitive inhibition with EGF or insulin C-peptide Rattus norvegicus
3.4.24.56 N-ethylmaleimide
-
Rattus norvegicus
3.4.24.56 PMSF 14.4% inhibition Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.56 110000
-
SDS-PAGE Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.56 Rattus norvegicus
-
rat, Sprague-Dawley
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.56
-
Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.56 amylin + H2O
-
Rattus norvegicus ?
-
?
3.4.24.56 beta-amyloid peptide + H2O
-
Rattus norvegicus ?
-
?
3.4.24.56 insulin + H2O
-
Rattus norvegicus ?
-
?
3.4.24.56 additional information EGF and insulin C-peptide are no substrates Rattus norvegicus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.56 IDE
-
Rattus norvegicus
3.4.24.56 Insulin-degrading enzyme
-
Rattus norvegicus