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Literature summary extracted from
- Catalytic peptide of human glutaminyl-tRNA synthetase is essential for its assembly to the aminoacyl-tRNA synthetase complex (2000), J. Biol. Chem., 275, 21768-21772.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 6.1.1.18 | overexpression of various Myc-tagged enzyme mutants in human embryonic kidney 293 cells | Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 6.1.1.18 | additional information | a deletion mutant comprising only the C-terminal catalytic domain is targeted into the multienzyme complex, while a deletion mutant comprising only the N-terminal domain is not | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 6.1.1.18 | ATP + L-glutamine + tRNAGln | Homo sapiens | - |
AMP + diphosphate + L-glutaminyl-tRNAGln | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 6.1.1.18 | Homo sapiens | - |
enzyme forms a macromolecular protein complex | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 6.1.1.18 | ATP + L-glutamine + tRNAGln | - |
Homo sapiens | AMP + diphosphate + L-glutaminyl-tRNAGln | - |
? | |
| 6.1.1.18 | ATP + L-glutamine + tRNAGln | tRNA substrate from bovine liver | Homo sapiens | AMP + diphosphate + L-glutaminyl-tRNAGln | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 6.1.1.18 | More | targeting into the multienzyme complex is mediated by the C-terminal catalytic domain | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 6.1.1.18 | Glutaminyl-tRNA synthetase | - |
Homo sapiens |
| 6.1.1.18 | QRS | - |
Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 6.1.1.18 | 7.5 | - |
assay at | Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 6.1.1.18 | ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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