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Literature summary extracted from

  • Howard, K.M.; Olson, M.S.
    The expression and localization of plasma platelet-activating factor acetylhydrolase in endotoxemic rats (2000), J. Biol. Chem., 275, 19891-19896.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.47 lipopolysaccharides induce plasma enzyme expression in several tissues, overview, induction is 50% inhibited by administration of antagonists BN 50739 and WEB 2170 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.47 BN 50739 antagonists of lipopolysaccharides, inhibition of induction of plasma enzyme expression Rattus norvegicus
3.1.1.47 WEB 2170 antagonists of lipopolysaccharides, inhibition of induction of plasma enzyme expression Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.47 extracellular
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O Rattus norvegicus i.e. platelet-activation factor, the enzyme hydrolyzes and inactivates platelet-activating factor PAF and PAF-like phospholipids which are implicated in numerous pathological situations including bacterial endotoxemia and injury-induced oxidative damage 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.47 Rattus norvegicus
-
 healthy and endotoxemic rats, plasma type enzyme
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.1.47 glycoprotein
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.47 blood plasma isozyme Rattus norvegicus
-
3.1.1.47 kidney
-
 Rattus norvegicus
-
3.1.1.47 Kupffer cell only after induction of plasma isozyme expression by lipopolysaccharides Rattus norvegicus
-
3.1.1.47 leukocyte circulating Rattus norvegicus
-
3.1.1.47 liver lobule, Kupffer cells Rattus norvegicus
-
3.1.1.47 lung
-
 Rattus norvegicus
-
3.1.1.47 macrophage resident ones of the liver, and peritoneal Rattus norvegicus
-
3.1.1.47 plasma
-
 Rattus norvegicus
-
3.1.1.47 spleen
-
 Rattus norvegicus
-
3.1.1.47 thymus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor Rattus norvegicus 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?
3.1.1.47 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O i.e. platelet-activation factor, the enzyme hydrolyzes and inactivates platelet-activating factor PAF and PAF-like phospholipids which are implicated in numerous pathological situations including bacterial endotoxemia and injury-induced oxidative damage Rattus norvegicus 1-alkyl-sn-glycero-3-phosphocholine + acetate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.47 PAF acetylhydrolase
-
 Rattus norvegicus
3.1.1.47 PAF-AH
-
 Rattus norvegicus
3.1.1.47 platelet-activating factor acetylhadrolase
-
 Rattus norvegicus