EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.1.1.47 | lipopolysaccharides | induce plasma enzyme expression in several tissues, overview, induction is 50% inhibited by administration of antagonists BN 50739 and WEB 2170 | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.1.47 | BN 50739 | antagonists of lipopolysaccharides, inhibition of induction of plasma enzyme expression | Rattus norvegicus | |
3.1.1.47 | WEB 2170 | antagonists of lipopolysaccharides, inhibition of induction of plasma enzyme expression | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.1.1.47 | extracellular | - |
Rattus norvegicus | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.47 | 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O | Rattus norvegicus | i.e. platelet-activation factor, the enzyme hydrolyzes and inactivates platelet-activating factor PAF and PAF-like phospholipids which are implicated in numerous pathological situations including bacterial endotoxemia and injury-induced oxidative damage | 1-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.1.47 | Rattus norvegicus | - |
healthy and endotoxemic rats, plasma type enzyme | - |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
3.1.1.47 | glycoprotein | - |
Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.1.47 | blood | plasma isozyme | Rattus norvegicus | - |
3.1.1.47 | kidney | - |
Rattus norvegicus | - |
3.1.1.47 | Kupffer cell | only after induction of plasma isozyme expression by lipopolysaccharides | Rattus norvegicus | - |
3.1.1.47 | leukocyte | circulating | Rattus norvegicus | - |
3.1.1.47 | liver | lobule, Kupffer cells | Rattus norvegicus | - |
3.1.1.47 | lung | - |
Rattus norvegicus | - |
3.1.1.47 | macrophage | resident ones of the liver, and peritoneal | Rattus norvegicus | - |
3.1.1.47 | plasma | - |
Rattus norvegicus | - |
3.1.1.47 | spleen | - |
Rattus norvegicus | - |
3.1.1.47 | thymus | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.47 | 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O | i.e. platelet-activation factor | Rattus norvegicus | 1-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? | |
3.1.1.47 | 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O | i.e. platelet-activation factor, the enzyme hydrolyzes and inactivates platelet-activating factor PAF and PAF-like phospholipids which are implicated in numerous pathological situations including bacterial endotoxemia and injury-induced oxidative damage | Rattus norvegicus | 1-alkyl-sn-glycero-3-phosphocholine + acetate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.1.47 | PAF acetylhydrolase | - |
Rattus norvegicus |
3.1.1.47 | PAF-AH | - |
Rattus norvegicus |
3.1.1.47 | platelet-activating factor acetylhadrolase | - |
Rattus norvegicus |