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Literature summary extracted from

  • Galliano, M.F.; Huet, C.; Frygelius, J.; Polgren, A.; Wewer, U.M.; Engvall, E.
    Binding of ADAM12, a marker of skeletal muscle regeneration, to the muscle-specific actin-binding protein, alpha-actinin-2, is required for myoblast fusion (2000), J. Biol. Chem., 275, 13933-13939.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B10 expression of the enzymes cytoplasmic tail including or missing the alpha-actinin-2-binding site, tagged with a myristolation motif in C2C12 myoblast cells, in vitro transcription and translation of the enzyme, expression of the enzymes cytoplasmic tail including or missing the alpha-actinin-2-binding site as GST-fusion proteins in Escherichia coli XL-1 Blue Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.B10 additional information construction of deletion mutants comprising the cytoplasmic tail with or without the alpha-actinin-2-binding site Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.B10 membrane integral Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B10 additional information Mus musculus enzyme is a marker of skeletal muscle regeneration, binds to alpha-actinin-2 via a specific binding site, and is required for myoblast fusion ?
-
 ?
3.4.24.B10 protein + H2O Mus musculus
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B10 Mus musculus Q61824
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.B10 C2C12 cell yoblast cell line Mus musculus
-
3.4.24.B10 myoblast C2C12 cell line, low content, is required for myoblast fusion Mus musculus
-
3.4.24.B10 skeletal muscle highly up-regulated in newly formed muscle fibers, enzyme is a marker of skeletal muscle regeneration, strongly binds to alpha-actinin-2 at the enzymes cytoplasmic tail Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B10 additional information enzyme is a marker of skeletal muscle regeneration, binds to alpha-actinin-2 via a specific binding site, and is required for myoblast fusion Mus musculus ?
-
 ?
3.4.24.B10 protein + H2O
-
 Mus musculus peptides
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B10 a disintegrin and metalloproteinase domain 12
-
 Mus musculus
3.4.24.B10 ADAM 12
-
 Mus musculus
3.4.24.B10 ADAM12
-
 Mus musculus
3.4.24.B10 M12.212 Merops-ID Mus musculus
3.4.24.B10 meltrin alpha
-
 Mus musculus