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Literature summary extracted from

  • Boone, A.N.; Chan, A.; Kulpa, J.E.; Brownsey, R.W.
    Bimodal activation of acetyl-CoA carboxylase by glutamate (2000), J. Biol. Chem., 275, 10819-10825.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.4.1.2 citrate
-
 Rattus norvegicus
6.4.1.2 glutamate role as physiological activator postulated, 4fold activation in absence of citrate, affects phosphorylation of enzyme Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.4.1.2 NaCl 30% inhibition at 100 mM Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.4.1.2 ATP + acetyl-CoA + HCO3- Rattus norvegicus key enzyme of fatty acid biosynthesis ADP + phosphate + malonyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.4.1.2 Rattus norvegicus
-
 male Wistar rats
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
6.4.1.2 phosphoprotein down-regulates enzyme activity Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.4.1.2 ATP + acetyl-CoA + HCO3-
-
 Rattus norvegicus ADP + phosphate + malonyl-CoA
-
 ?
6.4.1.2 ATP + acetyl-CoA + HCO3- key enzyme of fatty acid biosynthesis Rattus norvegicus ADP + phosphate + malonyl-CoA
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
6.4.1.2 biotin enzyme-bound Rattus norvegicus